Registration for a live webinar on 'Neuroleptic malignant syndrome' is now open.
See webinar details
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Models of Investigation
-
41 min
1. Antifungal innate immunity in C. elegans- Dr. Jonathan Ewbank
-
44 min
2. The anti-microbial defense of Drosophila: a paradigm for innate immunity- Prof. Jules Hoffmann
-
38 min
3. Phagocytosis in the fruit fly, Drosophila melanogaster- Dr. Lynda Stuart
-
62 min
4. Innate immune sensing and response- Prof. Bruce Beutler
-
61 min
5. Macrophages and systems biology- Prof. David Hume
- Cell Types and Recruitment
-
71 min
6. Leukocyte recruitment in vivo- Prof. Paul Kubes
-
51 min
-
42 min
8. Eosinophils- Prof. Tim Williams
-
63 min
9. Dendritic cells: linking innate to different forms of adaptive immunity- Prof. Ralph Steinman
-
25 min
-
61 min
11. Innate-like lymphocytes 1- Prof. Adrian Hayday
-
41 min
12. Innate-like lymphocytes 2- Prof. Adrian Hayday
- Recognition and Signaling
-
50 min
13. Colony stimulating factor-1 regulation of macrophages in development and disease- Prof. E. Richard Stanley
-
42 min
14. Fc receptors: linking innate and acquired immunity- Prof. Ken G C Smith
-
39 min
15. Phagocytosis- Prof. Joel Swanson
-
44 min
16. Clearance of apoptotic cells and the control of inflammation- Prof. Sir John Savill
-
38 min
17. Signaling by innate immune receptors- Prof. Michael Karin
-
41 min
18. Nuclear receptors at the crossroads of inflammation and atherosclerosis- Prof. Christopher Glass
- Modulation of Effector Responses
-
22 min
19. Humoral innate immunity and the acute phase response 1- Prof. Alberto Mantovani
-
42 min
20. Humoral innate immunity and the acute phase response 2- Prof. Alberto Mantovani
-
54 min
21. Cytokines regulating the innate response- Prof. Anne O’Garra
-
39 min
22. Arginase and nitric oxide- Dr. Peter Murray
-
38 min
23. Novel lipid mediators in resolution of inflammation- Prof. Charles Serhan
-
69 min
-
42 min
25. Cationic peptides in innate immunity- Dr. Dawn Bowdish
-
27 min
26. Iron metabolism and innate immunity- Prof. Tomas Ganz
- Pathogen-Host Interactions
-
46 min
27. Innate recognition of viruses- Prof. Caetano Reis e Sousa
-
50 min
28. Type I interferons in innate immunity to viral infections- Prof. Christine Biron
-
56 min
29. HIV-1 and immunopathogenesis: innate immunity- Prof. Luis Montaner
-
53 min
30. Understanding and combating tuberculosis- Prof. David Russell
-
34 min
-
51 min
32. Innate immunity and malaria- Prof. Douglas Golenbock
- Health and Disease
-
39 min
33. Innate immunity in children- Prof. David Speert
-
59 min
34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis- Prof. Sir Ravinder Maini
-
33 min
35. NOD-like receptors in innate immunity and inflammatory disease- Prof. Gabriel Nunez
-
38 min
36. Paneth cells in innate immunity and inflammatory bowel disease- Prof. Satish Keshav
-
36 min
37. Innate immunity in the brain in health and disease- Prof. V. Hugh Perry
-
54 min
38. The fate of monocytes in atherosclerosis- Prof. Gwendolyn Randolph
-
49 min
39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
-
73 min
40. Monocyte/macrophages in innate immunity- Prof. Emeritus Siamon Gordon
-
32 min
41. Innate immunity in C. elegans- Dr. Jonathan Ewbank
-
51 min
-
39 min
43. NLR genes: infection, inflammation and vaccines- Prof. Jenny Ting
-
63 min
44. Manipulation of innate immune response: lessons from shigella- Prof. Philippe Sansonetti
-
35 min
45. Innate immunity of the lung and adaptation to air breathing at birth- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- Intravital imaging of macrophages
- Macrophages functions
- TAMs subvert normal macrophage functions
- Tumor-stroma interactions
- TAMs density and prognosis
- CSF-1 and macrophage chemokines
- CSF-1 promotes tumor progression to metastasis?
- A robust staging system for PyMT tumors
- Delayed tumor progression without macrophages
- Pulmonary metastasis inhibition
- CSF-1 and tumor regulation
- CSF-1 expression in mammary gland
- Macrophages staining in the -/- (CSF-1 Tg+) mice
- Tumor progression at 18 weeks of age
- TAMs density in tumor
- Macrophages promote invasive microenvironment
- Tumor cells migration and macrophages
- Micro needle invasion assay
- Needle collection and CSF-1 and EGF signalling
- Cell specific gene expression profiles
- Needle collection of cells requires macrophages
- Tumor cell macrophage interaction
- Macrophages and tumor cells
- Paracrine loop-relayed chemotaxis
- The six traits
- Vessel network formation and tumor progression
- Malignancy and the angiogenic switch
- Stage of macrophages recruitment
- Angiogenesis mechanism
- Vessel network formation in WT/ CSF1 null mice
- Macrophage depletion reduces vascularization
- Macrophage depletion and vessel area and density
- IHC of VEGF in PyMT tumor
- VEGF expression vector using the 2A system
- VEGF effect
- VEGF over-expression
- Introducing macrophages in an earlier stage
- CSF-1 effect
- CSF-1 over expression
- CSF-1 transgenic expression
- Tumor movement and macrophages
- Where do the macrophages localize?
- Tumor cell motility
- Intravasation
- The invasive microenvironment
- Paracrine interactions
- Acknowledgements
Topics Covered
- Tumor microenvironment
- Macrophages promote tumor progression and metastasis
- Macrophage densities correlate with poor prognosis in many human cancers
- Macrophages regulate tumor cell migration and intravasation
- Macrophages regulate the angiogenic switch at the malignant transition
- Macrophage and tumor cells move using a paracrine mechanism involving CSF-1 and EGF
- Macrophages synthesize VEGF to regulate angiogenesis
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Pollard, J. (2009, May 31). Macrophages, a cellular toolbox used by tumors to promote progression and metastasis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 12, 2024, from https://doi.org/10.69645/PYUH4089.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Jeffrey Pollard has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Macrophages, a cellular toolbox used by tumors to promote progression and metastasis
Published on May 31, 2009
49 min
A selection of talks on Oncology
Hide