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- Models of Investigation
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1. Antifungal innate immunity in C. elegans
- Dr. Jonathan Ewbank
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2. The anti-microbial defense of Drosophila: a paradigm for innate immunity
- Prof. Jules Hoffmann
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3. Phagocytosis in the fruit fly, Drosophila melanogaster
- Dr. Lynda Stuart
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4. Innate immune sensing and response
- Prof. Bruce Beutler
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5. Macrophages and systems biology
- Prof. David Hume
- Cell Types and Recruitment
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6. Leukocyte recruitment in vivo
- Prof. Paul Kubes
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8. Eosinophils
- Prof. Tim Williams
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9. Dendritic cells: linking innate to different forms of adaptive immunity
- Prof. Ralph Steinman
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11. Innate-like lymphocytes 1
- Prof. Adrian Hayday
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12. Innate-like lymphocytes 2
- Prof. Adrian Hayday
- Recognition and Signaling
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13. Colony stimulating factor-1 regulation of macrophages in development and disease
- Prof. E. Richard Stanley
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14. Fc receptors: linking innate and acquired immunity
- Prof. Ken G C Smith
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15. Phagocytosis
- Prof. Joel Swanson
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16. Clearance of apoptotic cells and the control of inflammation
- Prof. Sir John Savill
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17. Signaling by innate immune receptors
- Prof. Michael Karin
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18. Nuclear receptors at the crossroads of inflammation and atherosclerosis
- Prof. Christopher Glass
- Modulation of Effector Responses
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19. Humoral innate immunity and the acute phase response 1
- Prof. Alberto Mantovani from humanitas.it
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20. Humoral innate immunity and the acute phase response 2
- Prof. Alberto Mantovani from humanitas.it
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21. Cytokines regulating the innate response
- Prof. Anne O’Garra
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22. Arginase and nitric oxide
- Dr. Peter Murray
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23. Novel lipid mediators in resolution of inflammation
- Prof. Charles Serhan
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25. Cationic peptides in innate immunity
- Dr. Dawn Bowdish
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26. Iron metabolism and innate immunity
- Prof. Tomas Ganz
- Pathogen-Host Interactions
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27. Innate recognition of viruses
- Prof. Caetano Reis e Sousa
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28. Type I interferons in innate immunity to viral infections
- Prof. Christine Biron
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29. HIV-1 and immunopathogenesis: innate immunity
- Prof. Luis Montaner
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30. Understanding and combating tuberculosis
- Prof. David Russell
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32. Innate immunity and malaria
- Prof. Douglas Golenbock
- Health and Disease
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33. Innate immunity in children
- Prof. David Speert
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34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis
- Prof. Sir Ravinder Maini
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35. NOD-like receptors in innate immunity and inflammatory disease
- Prof. Gabriel Nunez
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36. Paneth cells in innate immunity and inflammatory bowel disease
- Prof. Satish Keshav
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37. Innate immunity in the brain in health and disease
- Prof. V. Hugh Perry
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38. The fate of monocytes in atherosclerosis
- Prof. Gwendolyn Randolph
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39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis
- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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40. Monocyte/macrophages in innate immunity
- Prof. Emeritus Siamon Gordon
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41. Innate immunity in C. elegans
- Dr. Jonathan Ewbank
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43. NLR genes: infection, inflammation and vaccines
- Prof. Jenny Ting
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44. Manipulation of innate immune response: lessons from shigella
- Prof. Philippe Sansonetti
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45. Innate immunity of the lung and adaptation to air breathing at birth
- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- Lecture acknowledgements
- Lecture outline
- Section 1 outline
- Global review: viral life cycle
- Viral transmission
- Global review: acute infection
- Global review: acute infection (2)
- Mechanism of viral entry
- Systemic spread of the virus post entry
- CD4+ depletion in the gut
- How does GALT depletion affect disease outcome
- Why does the viral load drop?
- The host immune response
- Viral "set point" as a predictor of disease
- Course of disease
- Innate and adaptive immune responses cross talk
- Monocytes and macrophages compartments
- Monocytes and macrophages: virus reservoirs
- Macrophages and HIV-1 infection
- HIV-1 and monocyte apoptosis
- Human DC subsets
- Model of DC migration and maturation
- MHC I antigen presentation
- Antigen presentation on MHC class I and II
- Proposed pathways of human DC development
- Characteristics of human DC
- DC role during HIV-1 infection
- Dendritic cell subsets
- DC decrease upon HIV infection
- Human DC: C-type lectins
- Types of C-type lectins expressed on DC
- Pathogens that bind DC-SIGN
- Natural killer (NK) cells
- Direct cytotoxicity through CD8+ T cells
- Natural killer cell recognition of target cells (1)
- Natural killer cell recognition of target cells (2)
- MHC class I locus and NK cells regulation
- The role of NK cell throughout the disease
- Role of HLA and KIR alleles in progression to AIDS
- NK cell and HIV-1 infection
- To kill or not to kill?
- Measuring the recovery of patients
- ART & innate reconstitution
- RO1 AI51225 - prospective study
- Recovery of PDC function with HIV-1 suppression
- Reconstitution of PDC and NK cytotoxicity
- Model of immune reconstitution time line
- Section 1 conclusions
- Section 2 outline
- Recent paradigm shift: viral load and CD4 loss
- Immune activation and disease progression
- Natural SIV host
- Natural host vs. the HIV model
- TLR7 and TLR9 signaling and immune activation
- HIV-1 Nef and immune activation
- LPS levels are increased in chronic HIV infection
- Human Toll-like Receptors (TLRs)
- HIV RNAs can activate T cells via TLR 7, 8
- TLR activation and CD4 T cells apoptosis
- TLR induce human T cell activation and death
- Immune activation hypothesis
- Disease model
- Summary model
- Major hypothesis
- Thank you
Topics Covered
- Viral life cycle
- Acute infections
- Immune response
- Timeline to effectors
- Stages of immunopathogenesis
- Macrophages and HIV-1 infection
- Monocyte apoptosis
- Human DC subsets
- Model of DC migration and maturation
- MHC I antigen presentation
- Proposed pathways of human DC development
- C-type lectins
- Nature killer cells
- Natural killer cell recognition of target cells
- Role of HLA and KIR alleles in rate of progression to AIDS
- Measuring recovery following immune reconstitution and HIV-1 therapy
- ART and innate reconstitution
- Model of immune reconstitution timeline
- Does the innate immune activation response determine HIV-1 disease?
- Disease models: it's the activation
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Montaner, L. (2009, May 31). HIV-1 and immunopathogenesis: innate immunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 8, 2024, from https://doi.org/10.69645/DQSG2583.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Luis Montaner has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.