• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

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Navigable Slide Index

1. Introduction
2. T cell activation
3. Dendritic cells (DC)
4. Immune activation (1)
5. Pattern recognition
6. Bug recognition by Toll-like receptors in mammals
7. PRRs: coupling innate and adaptive immunity
8. Immune activation (2)
9. Viruses induce type I/III interferons
10. Induction of type I interferons is pattern recognition
11. Pattern recognition of viruses
12. IFN-alpha production and cytoplasmic dsRNA
13. IFN-alpha/beta induction by cytoplasmic dsRNA
14. Influenza virus
15. Influenza NS1 protein blocks IFN-a/b production
16. Cytoplasmic recognition of flu
17. Induction of IFN-a does not correlate with dsRNA
18. RIG-I mediated flu sensing
19. Transfection with flu vRNA is sufficient to elicit IFN
20. RIG-I binds directly to flu vRNA
21. RIG-I mediated sensing of flu genomes
22. Induction of type I/III interferons
23. Recognition is specific to vRNA
24. CIP abrogates the ability of flu vRNA to induce IFN
25. Conclusions (1)
26. 5' PPP RNA binds to the CTD of RIG-I
27. Why RIG-I doesn't mediate responses to EMCV
28. What about self ssRNA?
29. The actual RIG-I agonist during virus infection
30. IFN-a/b induction by viruses - Cytosolic pathways
31. Mouse DC subsets
32. pDC make lots of IFN-a in response to wild type flu
33. Conclusions (2)
34. pDC responses to flu require TLR7
35. Endosomal recognition of viruses
36. Virus recognition pathways
37. TLR7 recognises poly U clusters
38. TLR7 recognises self mRNA
39. Conclusions (3)
40. What about apoptotic cells? (1)
41. Spleen DC subsets
42. Scavenging by CD8-alpha positive DC
43. What about apoptotic cells? (2)
44. CD8a+ DC do not express TLR7 but express TLR3
45. DC "decode" signs of infection within dying cells
46. Detecting virally-infected cells
47. Replication of some viruses generates dsRNA
48. DC activation by virally-infected cells
49. Virus-infected cells induce CTL responses
50. CTL priming after TLR3-mediated dsRNA sensing
51. Summary
52. Acknowledgements

Topics Covered

• Induction of the adaptive Immunity
• Pattern recognition receptors: coupling innate to adaptive immunity
• Induction of type I IFNs: an example of recognition of viral patterns
• Cytosolic pathway for influenza virus recognition and inhibition by the viral
• NSI protein
• RIG-I-mediated recognition of influenza virus genomes and 5'-PPP-RNA
• Cytosolic 5'-PPP-RNA as a PAMP
• Plasmacytoid DC and the discovery of a second pathway for innate recognition of influenza virus
• Endosomal pathways for virus recognition: TLR7, TLR9
• TLR3 as a sensor of virally-infected cells

Links

Series:

• Innate Immunity

Categories:

• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on June 30, 2009

Financial Disclosures

• Prof. Caetano Reis e Sousa has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.