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Printable Handouts
Navigable Slide Index
- Introduction
- Disclosures
- Overview
- Phosphate is vital for several key biological processes
- Phosphate homeostasis regulation
- Key players in phosphate homeostasis
- Pathophysiology of acute hypophosphataemia
- Pathophysiology of chronic hypophosphataemia
- Symptoms of low phosphate
- Biochemical investigations
- Disorders of hypophosphataemia
- Case study 1
- Case study 1: 3.5-year-old boy
- Case study 1: clinical presentation
- Case study 1: biochemical picture
- Approach to hypophosphataemia
- Case study 1: management
- Preventing nutritional rickets
- Case study 2
- Case study 2: 3.5-year-old boy
- Case study 2: progress
- Case study 2: biochemical picture
- Approach to hypophosphataemia
- Differentials of FGF23-mediated hypophosphataemia
- X-linked hypophosphataemia
- Autosomal dominant hypophosphataemic rickets
- ARHR type 1
- ARHR type 2 (ARHR2)
- ARHR2
- ARHR type 3 (ARHR 3)
- Fibrous Dysplasia (FD)
- Fibrous dysplasia
- Tumour-Induced Osteomalacia (TIO)
- TIO: clinical features
- TIO & imaging
- Approach to hypophosphataemia
- Hypophosphataemic rickets with hypercalciuria
- Fanconi syndrome
- Summary
Topics Covered
- The spectrum of hypophosphataemia in children
- Phosphate homeostasis
- Pathophysiology of hypophosphataemia
- Acute and chronic hypophosphataemia
- Management of hypophosphataemia
- Rickets
- Hereditary Hypophosphataemic Rickets with Hypercalciuria (HHRH)
- Tumour Induced Osteomalacia (TIO)
- X linked hypophosphataemia (XLH)
- FGF23-mediated hypophosphataemia
- Autosomal Dominant Hypophosphataemic Rickets (ADHR)
- Autosomal Recessive Hypophosphataemic Rickets (ARHR)
- Fibrous Dysplasia (FD)
- Fanconi syndrome
Links
Categories:
Therapeutic Areas:
External Links
Talk Citation
Uday, S. (2024, March 31). Spectrum of hypophosphatemia in children [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 7, 2024, from https://doi.org/10.69645/AECV4081.Export Citation (RIS)
Publication History
Financial Disclosures
- Honorarium, travel grants and research grants from Alexion, Kyowa Kirin, Novo Nordisk, Sanofi, Internis. Expert panel member on the International Hypophosphataemia Network, a Kyowa Kirin information hub for healthcare professionals
A selection of talks on Clinical Practice
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is Suma Uday.
I am a consultant
endocrinologist at
Birmingham Children's Hospital,
in Birmingham, in the UK.
I am also an Honorary
Associate Clinical Professor
at the University of Birmingham.
The topic of my
discussion today is
the clinical spectrum
of hypophosphataemia,
that is low phosphate
in children.
I would like to sincerely thank
Henry Stewart Talks for
inviting me to
deliver this lecture.
0:31
These are my disclosures:
I would like to specifically
mention that I am
an expert panel member on
the International
Hypophospotemia Network,
which is a Kyowa
Kirin information hub
for healthcare professionals.
Some of the educational
material that I will be
using today were developed for
the purpose of this network.
0:51
Over the next 30 minutes or so,
I will detail the spectrum of
conditions caused by
hypophosphataemia.
As the title suggests,
the scope of this talk is to
provide an overview of
the various conditions
only and not to discuss
the diagnosis and management
of each of these in depth.
I will start with a brief
overview of the role
of phosphate in humans and
phosphate homeostasis.
I will detail the
clinical features
of low phosphate and provide
a logistic approach
to investigating
children presenting
with hypophosphataemia,
which focuses on
the assessment of
pathophysiologic
mechanisms that lead
to low serum phosphate
concentrations.
Through some case studies,
I will elaborate on these
specific conditions.
Phosphate is one of