Spectrum of hypophosphatemia in children

Published on March 31, 2024   34 min

A selection of talks on Cardiovascular & Metabolic

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Hello, my name is Suma Uday. I am a consultant endocrinologist at Birmingham Children's Hospital, in Birmingham, in the UK. I am also an Honorary Associate Clinical Professor at the University of Birmingham. The topic of my discussion today is the clinical spectrum of hypophosphataemia, that is low phosphate in children. I would like to sincerely thank Henry Stewart Talks for inviting me to deliver this lecture.
These are my disclosures: I would like to specifically mention that I am an expert panel member on the International Hypophospotemia Network, which is a Kyowa Kirin information hub for healthcare professionals. Some of the educational material that I will be using today were developed for the purpose of this network.
Over the next 30 minutes or so, I will detail the spectrum of conditions caused by hypophosphataemia. As the title suggests, the scope of this talk is to provide an overview of the various conditions only and not to discuss the diagnosis and management of each of these in depth. I will start with a brief overview of the role of phosphate in humans and phosphate homeostasis. I will detail the clinical features of low phosphate and provide a logistic approach to investigating children presenting with hypophosphataemia, which focuses on the assessment of pathophysiologic mechanisms that lead to low serum phosphate concentrations. Through some case studies, I will elaborate on these specific conditions. Phosphate is one of