Role of growth hormone in aging

Published on April 30, 2023   46 min

A selection of talks on Metabolism & Nutrition

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Our topic today is the regulation of mammalian aging by growth hormone.
Before going into this topic, I thought we can spend a few moments thinking about what is the reason that we're interested in studying aging, and why we feel that this research may be important.
What is shown in this image is the incidence of a variety of chronic diseases: heart conditions, diabetes, dementia, and so forth, and also all-cause mortality. What is obvious is that the incidence of all of this, the risk for all those diseases increases very much with age. In many cases, aging is, in fact, the most important risk factor with nothing really coming close. Please note that these data are plotted on the logarithmic scale. In other words, if this was a linear scale, the lines would have been almost vertical. It's a very dramatic increase in the risk factor with age. Now, most people working in the biology of aging including our group, feel this data along with other evidence implies that if we could reduce the rate of aging if we could inhibit their biological process of aging, we could produce an important reduction in the risk of all these diseases. That, in fact, we could postpone them or make them less common. There is considerable evidence from work in experimental animals showing that this goal, even though it may appear to be very difficult, is probably realistic. That, in fact, in situations where we can slow the aging process and extend longevity, we also postpone the onset of aging-related diseases, and we can reduce their incidence. Since we are interested in,