Vitamin E and the metabolic syndrome

Published on February 28, 2019   34 min

A selection of talks on Pharmaceutical Sciences

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Hello, I'm Maret Traber. I'm at the Linus Pauling Institute at Oregon State University in Corvallis, Oregon in the United States. Today I'd like to talk to you about our studies concerning vitamin E and persons with metabolic syndrome.
I'd like to cover the topics of what is metabolic syndrome, then briefly review what is known about vitamin E absorption and transport, cover interesting new studies concerning vitamin E pharmacokinetics in metabolic syndrome subjects, and then, finally, tell you about a new vitamin E biomarker Alpha-CEHC. We'll cover results from two different trials; one is a UCLA diet study and the other is the results from the pharmacokinetic study that was done in metabolic syndrome subjects at Ohio State University.
So, what is the metabolic syndrome? In general, these are a series of abnormalities including elevated blood pressure, high blood sugar, excess visceral body fat, elevated circulating triglycerides, and low HDL cholesterol. This diagnosis is made clinically when a person has three out of five of these components including waist circumference that is too large, elevated blood pressure, elevated triglycerides, low HDL cholesterol, and elevated plasma glucose. Note that the elevations can still be within the normal range, but it is the combination that is concernful.