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Printable Handouts
Navigable Slide Index
- Introduction
- Relapse in obesity treatment
- Why is weight loss maintenance so difficult?
- Weight regain is driven by physiological adaptations
- Compensatory theory
- Physiological adapations to the weight-reduced state
- Metabolic adaptation in response to weight loss?
- Longitudinal studies find metabolic adapation
- Further evidence of metabolic adaptation
- Does metabolic adaptation predict weight regain?
- No evidence metabolic adaptation predicts weight regain
- Study 1: metabolic adaptation over time (USA)
- Study 1: results
- Study 1: subgroup analysis
- Study 1: is there an association?
- Study 2: metabolic adaptation over time (Norway)
- Metabolic reduction in weight stable participants
- Study 2: subgroup analysis
- Study 2: is there an association?
- Metabolic adaptation: an illusion?
- Considering energy balance status
- Metabolic adaptation is likely an artefact
- Conclusion
- Changes in appetite following weight loss
- Does increased appetite drive relapse?
- Study 1: does increased appetite drive relapse?
- Study 2: does increased appetite drive relapse?
- Study 3: does increased appetite drive relapse?
- What drives weight regain?
- Study design
- Results
- Changes in adaptive physiological mechanisms
- Increased ghrelin associated with decreased weight regain?
- Compensation or normalisation?
- Normalisation of GLP after weight loss
- Further evidence of normalisation after weight loss
- Compensation theory vs. normalisation theory
- Conclusions
- Acknowledgements
Topics Covered
- Drivers of weight regain
- Compensatory theory of weight regain
- Energy expenditure in weight regain
- Metabolic adaptation after weight loss
- Changes in appetite following weight loss
- Normalisation theory of weight regain
Links
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Talk Citation
Martins, C. (2022, January 31). Relapse in obesity management: does increased appetite and reduced energy expenditure play a role? [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/FXVN5767.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Cátia Martins has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Relapse in obesity management: does increased appetite and reduced energy expenditure play a role?
Published on January 31, 2022
33 min
A selection of talks on Metabolism & Nutrition
Transcript
Please wait while the transcript is being prepared...
0:00
Hi, my name is Cátia Martins and I'm a professor of obesity and metabolism
at the Norwegian University of Science and Technology.
Today, I'm going to talk about relapse in obesity management and discuss with you
if increased appetite and reduced energy expenditure play a role in this process.
0:20
The biggest challenge in obesity management is not weight-loss.
The majority of the individuals with obesity are able to lose
clinically significant amounts of weight with different interventions.
The challenge is that the majority regain
at least some of the weight that they have worked so hard to lose in the long-term.
Some even relapse above baseline weight.
This happens regardless of the intervention that is used to induce weight loss-
different types of exercise, different diets,
combined behavioral interventions,
and even bariatric surgery.
0:59
There are two main theories that try to explain relapse and obesity treatment.
One is related to motivation and behavioral issues.
The lack of willpower and poor compliance to diet and exercise regime.
This idea is that patients will sooner or later revert
back to their old lifestyle of overeating and sedentary lifestyle.
This is related to a self-regulatory theory that restraint
is always followed by disinhibition or loss of inhibition.
The other view is related to physiology,
which is called the compensatory theory.
This theory claims that the body fights against weight loss
and tries to bring it back to its original state.
This theory claims that weight loss is
followed by a significant increase in the drive to eat,
despite a significant reduction in total energy expenditure.
Of course, both of these mechanisms,
both behavioral and physiology could then lead to weight regain in the long term.
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