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- Models of Investigation
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41 min
1. Antifungal innate immunity in C. elegans- Dr. Jonathan Ewbank
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44 min
2. The anti-microbial defense of Drosophila: a paradigm for innate immunity- Prof. Jules Hoffmann
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38 min
3. Phagocytosis in the fruit fly, Drosophila melanogaster- Dr. Lynda Stuart
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62 min
4. Innate immune sensing and response- Prof. Bruce Beutler
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61 min
5. Macrophages and systems biology- Prof. David Hume
- Cell Types and Recruitment
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71 min
6. Leukocyte recruitment in vivo- Prof. Paul Kubes
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51 min
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42 min
8. Eosinophils- Prof. Tim Williams
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63 min
9. Dendritic cells: linking innate to different forms of adaptive immunity- Prof. Ralph Steinman
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25 min
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61 min
11. Innate-like lymphocytes 1- Prof. Adrian Hayday
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41 min
12. Innate-like lymphocytes 2- Prof. Adrian Hayday
- Recognition and Signaling
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50 min
13. Colony stimulating factor-1 regulation of macrophages in development and disease- Prof. E. Richard Stanley
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42 min
14. Fc receptors: linking innate and acquired immunity- Prof. Ken G C Smith
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39 min
15. Phagocytosis- Prof. Joel Swanson
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44 min
16. Clearance of apoptotic cells and the control of inflammation- Prof. Sir John Savill
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38 min
17. Signaling by innate immune receptors- Prof. Michael Karin
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41 min
18. Nuclear receptors at the crossroads of inflammation and atherosclerosis- Prof. Christopher Glass
- Modulation of Effector Responses
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22 min
19. Humoral innate immunity and the acute phase response 1- Prof. Alberto Mantovani
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42 min
20. Humoral innate immunity and the acute phase response 2- Prof. Alberto Mantovani
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54 min
21. Cytokines regulating the innate response- Prof. Anne O’Garra
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39 min
22. Arginase and nitric oxide- Dr. Peter Murray
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38 min
23. Novel lipid mediators in resolution of inflammation- Prof. Charles Serhan
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69 min
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42 min
25. Cationic peptides in innate immunity- Dr. Dawn Bowdish
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27 min
26. Iron metabolism and innate immunity- Prof. Tomas Ganz
- Pathogen-Host Interactions
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46 min
27. Innate recognition of viruses- Prof. Caetano Reis e Sousa
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50 min
28. Type I interferons in innate immunity to viral infections- Prof. Christine Biron
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56 min
29. HIV-1 and immunopathogenesis: innate immunity- Prof. Luis Montaner
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53 min
30. Understanding and combating tuberculosis- Prof. David Russell
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34 min
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51 min
32. Innate immunity and malaria- Prof. Douglas Golenbock
- Health and Disease
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39 min
33. Innate immunity in children- Prof. David Speert
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59 min
34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis- Prof. Sir Ravinder Maini
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33 min
35. NOD-like receptors in innate immunity and inflammatory disease- Prof. Gabriel Nunez
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38 min
36. Paneth cells in innate immunity and inflammatory bowel disease- Prof. Satish Keshav
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36 min
37. Innate immunity in the brain in health and disease- Prof. V. Hugh Perry
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54 min
38. The fate of monocytes in atherosclerosis- Prof. Gwendolyn Randolph
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49 min
39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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73 min
40. Monocyte/macrophages in innate immunity- Prof. Emeritus Siamon Gordon
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32 min
41. Innate immunity in C. elegans- Dr. Jonathan Ewbank
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51 min
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39 min
43. NLR genes: infection, inflammation and vaccines- Prof. Jenny Ting
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63 min
44. Manipulation of innate immune response: lessons from shigella- Prof. Philippe Sansonetti
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35 min
45. Innate immunity of the lung and adaptation to air breathing at birth- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- Guide to the presentation
- Inflammation, an inducer and amplifier of diseases
- Mechanisms contributing to fatty streak formation
- Mechanisms contributing to lesion progression
- Mechanisms contributing to unstable lesions
- Risk factors for the development of atherosclerosis
- Risk factors and their relationship to inflammation
- Induction of inflammatory genes
- Toll like receptors and microbial pathogens
- Toll like receptors and endogenous ligands
- TLR4 and its roll in atherosclerosis
- Modulation of atherosclerosis in mice by TLR2
- Summary: inflammation and atherosclerosis
- TLR targets in the nucleus
- Induction of inflammatory response genes by LPS
- NCoR co-repressor complexes
- Conforming the NCoR complex model
- NCoR complex and signaling pathways
- Transcriptional control of inflammatory responses
- Nuclear receptor superfamily
- Transcriptional activities of nuclear receptors
- Regulation of the nuclear receptor expression
- Dexamethasone inhibition
- Glucocorticoid receptor repression
- Repression of LPS-responsive genes
- Nuclear receptors and inflammatory responses
- PPAR-gamma - structure, function and ligands
- PPAR-gamma expression in macrophages
- PPAR-gamma agonists
- PPAR-gamma ligands and foam cell formation
- Rosiglitazone inhibition
- PPAR-gamma ligands and atherosclerotic lesions
- Effect of Rosiglitazone on markers of inflammation
- NCoR SUMOylation-dependent mechanism
- NCoR and PPAR-gamma repression of iNOS
- NCoR, PPAR-gamma and iNOS
- Effects of TZDs on cardiovascular risk factors
- Adverse effects of TZDs
- PPAR-gamma-specific ligands summary
- Future prospects
- Acknowledgements
Topics Covered
- Nuclear receptors comprise a superfamily of ligand- and signal-dependent transcription factors that regulate diverse aspects of reproduction, development, metabolism and immunity
- Recent studies have demonstrated that a subset of nuclear receptors can co-ordinately regulate aspects of inflammation and metabolism that impact on the development of atherosclerosis and type 2 diabetes by inhibiting transcriptional responses to toll like receptors
- The nuclear receptor co-repressor NCoR plays a key role in maintaining inflammatory response genes in a repressed state under basal conditions
- PPARg inhibits inflammatory responses by preventing the removal of NCoR from target genes
Links
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Talk Citation
Glass, C. (2009, May 31). Nuclear receptors at the crossroads of inflammation and atherosclerosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/1297/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Christopher Glass has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Nuclear receptors at the crossroads of inflammation and atherosclerosis
Published on May 31, 2009
41 min
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