- Models of Investigation
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41 min
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44 min
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38 min
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62 min
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61 min
- Cell Types and Recruitment
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71 min
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51 min
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42 min
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63 min
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25 min
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61 min
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41 min
- Recognition and Signaling
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50 min
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42 min
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39 min
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44 min
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38 min
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41 min
- Modulation of Effector Responses
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22 min
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42 min
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54 min
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39 min
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38 min
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69 min
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42 min
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27 min
- Pathogen-Host Interactions
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46 min
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50 min
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56 min
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53 min
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34 min
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51 min
- Health and Disease
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39 min
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59 min
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33 min
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38 min
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36 min
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54 min
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49 min
- Archived Lectures *These may not cover the latest advances in the field
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73 min
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32 min
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51 min
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39 min
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63 min
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35 min
Topics Covered
- Nuclear receptors comprise a superfamily of ligand- and signal-dependent transcription factors that regulate diverse aspects of reproduction, development, metabolism and immunity
- Recent studies have demonstrated that a subset of nuclear receptors can co-ordinately regulate aspects of inflammation and metabolism that impact on the development of atherosclerosis and type 2 diabetes by inhibiting transcriptional responses to toll like receptors
- The nuclear receptor co-repressor NCoR plays a key role in maintaining inflammatory response genes in a repressed state under basal conditions
- PPARg inhibits inflammatory responses by preventing the removal of NCoR from target genes
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Glass, C. (2009, May 31). Nuclear receptors at the crossroads of inflammation and atherosclerosis [Video file]. In
The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 25, 2023, from
https://hstalks.com/bs/1297/.
Export Citation (RIS)
Publication History
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Published on May 31, 2009
Financial Disclosures
- Prof. Christopher Glass has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.