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- Models of Investigation
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41 min
1. Antifungal innate immunity in C. elegans- Dr. Jonathan Ewbank
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44 min
2. The anti-microbial defense of Drosophila: a paradigm for innate immunity- Prof. Jules Hoffmann
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38 min
3. Phagocytosis in the fruit fly, Drosophila melanogaster- Dr. Lynda Stuart
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62 min
4. Innate immune sensing and response- Prof. Bruce Beutler
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61 min
5. Macrophages and systems biology- Prof. David Hume
- Cell Types and Recruitment
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71 min
6. Leukocyte recruitment in vivo- Prof. Paul Kubes
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51 min
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42 min
8. Eosinophils- Prof. Tim Williams
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63 min
9. Dendritic cells: linking innate to different forms of adaptive immunity- Prof. Ralph Steinman
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25 min
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61 min
11. Innate-like lymphocytes 1- Prof. Adrian Hayday
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41 min
12. Innate-like lymphocytes 2- Prof. Adrian Hayday
- Recognition and Signaling
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50 min
13. Colony stimulating factor-1 regulation of macrophages in development and disease- Prof. E. Richard Stanley
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42 min
14. Fc receptors: linking innate and acquired immunity- Prof. Ken G C Smith
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39 min
15. Phagocytosis- Prof. Joel Swanson
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44 min
16. Clearance of apoptotic cells and the control of inflammation- Prof. Sir John Savill
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38 min
17. Signaling by innate immune receptors- Prof. Michael Karin
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41 min
18. Nuclear receptors at the crossroads of inflammation and atherosclerosis- Prof. Christopher Glass
- Modulation of Effector Responses
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22 min
19. Humoral innate immunity and the acute phase response 1- Prof. Alberto Mantovani
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42 min
20. Humoral innate immunity and the acute phase response 2- Prof. Alberto Mantovani
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54 min
21. Cytokines regulating the innate response- Prof. Anne O’Garra
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39 min
22. Arginase and nitric oxide- Dr. Peter Murray
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38 min
23. Novel lipid mediators in resolution of inflammation- Prof. Charles Serhan
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69 min
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42 min
25. Cationic peptides in innate immunity- Dr. Dawn Bowdish
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27 min
26. Iron metabolism and innate immunity- Prof. Tomas Ganz
- Pathogen-Host Interactions
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46 min
27. Innate recognition of viruses- Prof. Caetano Reis e Sousa
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50 min
28. Type I interferons in innate immunity to viral infections- Prof. Christine Biron
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56 min
29. HIV-1 and immunopathogenesis: innate immunity- Prof. Luis Montaner
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53 min
30. Understanding and combating tuberculosis- Prof. David Russell
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34 min
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51 min
32. Innate immunity and malaria- Prof. Douglas Golenbock
- Health and Disease
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39 min
33. Innate immunity in children- Prof. David Speert
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59 min
34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis- Prof. Sir Ravinder Maini
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33 min
35. NOD-like receptors in innate immunity and inflammatory disease- Prof. Gabriel Nunez
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38 min
36. Paneth cells in innate immunity and inflammatory bowel disease- Prof. Satish Keshav
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36 min
37. Innate immunity in the brain in health and disease- Prof. V. Hugh Perry
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54 min
38. The fate of monocytes in atherosclerosis- Prof. Gwendolyn Randolph
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49 min
39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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73 min
40. Monocyte/macrophages in innate immunity- Prof. Emeritus Siamon Gordon
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32 min
41. Innate immunity in C. elegans- Dr. Jonathan Ewbank
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51 min
-
39 min
43. NLR genes: infection, inflammation and vaccines- Prof. Jenny Ting
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63 min
44. Manipulation of innate immune response: lessons from shigella- Prof. Philippe Sansonetti
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35 min
45. Innate immunity of the lung and adaptation to air breathing at birth- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- Innate immunity and phagocytosis
- What is innate immunity?
- Innate immunity and the host-pathogen interaction
- The 1908 Nobel Laureates
- Phagocytic recognition (1)
- Phagocytic recognition (2)
- Phagosome maturation
- The phagosome
- The Drosophila phagosome
- Drosophila as a model system
- Drosophila as a model organism (1)
- Toll
- Drosophila as a model organism (2)
- Phagocytosis during Drosophila development
- Phagocytes in Drosophila embryos
- Surface receptors and particle recognition
- Receptors
- Immune signalling receptors
- Drosophila opsonins: TEPs
- Scavenger receptors
- EGF-containing receptors
- Down's Syndrome Cell Adhesion Molecule (1)
- Down's Syndrome Cell Adhesion Molecule (2)
- Removal of apoptotic cells
- Phagocytosis of cellular corpses
- Croquemort
- Simu and Draper
- Pallbearer
- Phagocytosis in host defense
- Phagocytosis in host defense (2)
- The contribution of phagocytosis to defense
- RNAi screens
- Acknowledgments
Topics Covered
- Infectious diseases remain the commonest cause of premature mortality worldwide
- The emergence of antibiotic resistant strains and the risks of bioterrorism have reinforced the importance of understanding the host-pathogen dynamic
- It is hopeful that identifying the natural mechanisms used by the host to control infection will provide new avenues for therapeutic intervention
- Model organisms such as Drosophila provide well-characterized, conserved and genetically tractable systems for exploring this dynamic
- Drosophila are amenable to not only forward and reverse genetics but also hold great promise for small molecule screening and other unbiased approaches that will uncover evolutionarily conserved components of the innate immune system
Talk Citation
Stuart, L. (2009, June 30). Phagocytosis in the fruit fly, Drosophila melanogaster [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved June 3, 2023, from https://hstalks.com/bs/1280/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Lynda Stuart has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Phagocytosis in the fruit fly, Drosophila melanogaster
Published on June 30, 2009
38 min
