Inflammation and immune cell entry to the central nervous system

Published on March 1, 2008 Reviewed on May 24, 2017   71 min

Other Talks in the Series: The Blood-Brain Barrier

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So it is exactly the Innate immunity.
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The presence of infections is recognized by receptors for a specific event called the Pathogen-Associated Molecular Patterns or the PAMPs. These PAMPs are produced by microorganisms, such as bacteria, or fungi and yeast. The recognition of these PAMPs by myeloid cells is the first step of a complex inflammatory reactions that characterizes the innate immune response. So the Endotoxin Lipopolysaccharide is a major component of the outer membranes of the Gram-negative bacteria, which is the best known target of innate recognition and induce a robust inflammatory response by phagocytes or phagocytic cells, if you want. We have many other PAMPs such as Peptidoglycan and so LTA from Gram-postive bacterias which are known common structural patterns that are recognized by host germ lines encoded receptors and induce stimulation of the nuclear factors called NF kappa B signaling pathways and cytokine synthesis.
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Inflammation and immune cell entry to the central nervous system

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