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- Fundamentals of Evolution and Medicine
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1. Evolutionary medicine
- Prof. Randolph Nesse
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2. Evolution and medicine: from the perspective of an evolutionary biologist
- Prof. Stephen C. Stearns
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3. Developmental plasticity, evolution and the origins of disease
- Dr. Mary Jane West-Eberhard
- Evolutionary Genetics
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4. Genetic variation and human disease
- Dr. David Houle
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6. Ecogenetics, evolutionary biology and human disease
- Prof. Gilbert Omenn
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7. Race in genetics and medicine
- Prof. Jeffrey Long
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8. Health disparities in common complex diseases: a role for genetics?
- Dr. Kathleen Barnes
- Infectious Disease
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10. Evolutionary arms races
- Prof. Mark Pagel
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11. Antibiotic resistance and hospital-acquired infection
- Dr. Carl Bergstrom
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12. Evolution of drug resistance
- Dr. Pleuni Pennings
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13. Evolution of virulence: malaria, a case study
- Prof. Andrew Read
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14. Infection and chronic disease
- Prof. Paul Ewald
- Defenses
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15. Fever and related defenses
- Prof. Matthew Kluger
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16. The evolutionary ecology of immunity
- Prof. Paul Schmid-Hempel
- Novel Environmental Factors
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17. What did humans evolve to eat? evolutionary perspectives on human nutritional health
- Prof. William R. Leonard
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19. The paleolithic lifestyle and prevention of chronic disease
- Prof. S. Boyd Eaton
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22. Diseases of civilization: an evolutionary legacy
- Prof. Alan Weder
- Problems Arising From Constraints and Trade-Offs
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23. Aging and evolutionary medicine
- Prof. Linda Partridge
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24. Human aging and menopause
- Prof. Kristen Hawkes
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25. Why we cook with spices: preventative darwinian medicine
- Prof. Paul Sherman
- Sex and Reproduction
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26. Setting the second stage: the evolution of menopause & post-reproductive life
- Prof. Lynnette Sievert
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27. Evolutionary obstetrics
- Prof. Wenda Trevathan
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28. Sex differences in mortality
- Dr. Daniel Kruger
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29. The endocrinology of human life history transitions
- Prof. Peter Ellison
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30. Genetic conflicts in human pregnancy
- Prof. David Haig
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31. Environmental effects on human reproduction
- Prof. Gillian Bentley
- Cancer
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32. A darwinian eye view of cancer
- Prof. Mel Greaves
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33. Viruses and cancer
- Prof. Robin Weiss
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34. Connecting aging and cancer through the lens of evolution
- Prof. James DeGregori
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35. Evolutionary dynamics in cancer control and cure
- Dr. Bob Gatenby
- Specific Body Systems
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36. Hard tissue biology in human health and evolution: enamel biology
- Prof. Timothy Bromage
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37. Hard tissue biology in human health and evolution: bone biology
- Prof. Timothy Bromage
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38. Hard tissue biology in human health and evolution: craniofacial biology
- Prof. Timothy Bromage
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39. Hard tissue biology in human health and evolution: life history and chronobiology
- Prof. Timothy Bromage
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40. Lung biology and lung disease
- Prof. John S. Torday
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41. The evolutionary web of life
- Prof. John S. Torday
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42. Evolutionary considerations and the endothelium
- Dr. William Aird
- Mental Disorders
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43. Evolutionary psychiatry
- Prof. Randolph Nesse
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44. Evolutionary behavioural genetics and mental disorders
- Dr. Matthew Keller
- Questions and Answers
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45. Audience questions about evolution and medicine
- Prof. Randolph Nesse
- Paediatrics
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46. Evolutionary pediatrics
- Dr. Paul Turke
- Microbiome
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47. Evolution, the microbiome, and human health
- Dr. Joe Alcock
- Archived Lectures *These may not cover the latest advances in the field
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48. The hygiene hypothesis
- Prof. Graham Rook
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49. Mapping motivations: evolutionary health promotion
- Dr. Valerie Curtis
- Dr. Robert Aunger
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50. Evolutionary biology of depression
- Prof. Lewis Wolpert
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51. Evolutionary genetic epidemiology
- Prof. Nicholas Schork
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52. Mental disorders in the light of evolutionary biology
- Prof. Randolph Nesse
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53. Evolution: medicine's missing basic science
- Prof. Randolph Nesse
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54. Environmental effects on human reproduction
- Prof. Gillian Bentley
Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Time is an essential ingredient in nature's pattern generator
- What enamel looks like in transverse section
- What happens if you describe lots of ringss on lots of trees?
- A baby tooth
- This is a curiosity
- Enamel incremental anatomy
- Long period rhythm in enamel?
- Understanding primate life history from enamel development
- The primate life history package
- An example
- Enamel rhythm - what's it all about?
- How about among early and modern humans?
- Multidien enamel rhythms and body size
- Summary of primate enamel repeat intervals and tissue/organ mass
- Lamellae are periodic growth lines in bone
- Primary and secondary lamellae are on the same growth schedule
- The relationship between enamel and bone formation
- The Havers-Halberg oscillation
- The key to a metabolism-mediated life history
- The primate life history package: what is missing?
- Relationship with gestation length
- Relationship with lactation length
- Relation with maximum lifespan
- Relationship with cranial capacity among primates
- Relationship with cranial capacity for early humans
- Relationship with BMR (W)
- Summary or primate enamel repeat intervals and life history
- What mechanisms explain the diversity of life?
- The swine metabolome
- 228 metabolites of high analytical grade
- SUS SCROFA 5-day enamel repeat period
- Cosinor analysis of a circadian rhythm
- The SUS SCROFA 5-day mutlidien metabolome
- A selection of 22 metabolites for animal #17 (23:00)
- The gene network describing the SUS SCROFA 5-day multidien metabolome
- The gene network describing the SUS SCROFA 5-day multidien sncRNA-OME
- The complete SUS SCROFA cross-correlation matrix
- Correlation between SUS SCROFA metabolites and sncRNAs
- The primate life history package
- Enamel striae of Retizus and modern human body size
- Multidien rhythms in hard tissue biology
- The significance of lamellae widths
- Time to fall asleep?
- Primary lamellar bone from the midshaft femur
- 66ZN/88SR concentrations of primary lamellar bone
- Acknowledgements
- Bibliography
Topics Covered
- Human tooth enamel forms growth increments
- Stria of Retzius and the enamel repeat interval
- The repeat interval varies across the order Primates and correlates with different characteristics
- Havers-Halberg Oscillation (HHO)
- Metabolomics and genomics research on the HHO
Talk Citation
Bromage, T. (2021, February 25). Hard tissue biology in human health and evolution: life history and chronobiology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 15, 2025, from https://doi.org/10.69645/OCZG9594.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
Hard tissue biology in human health and evolution: life history and chronobiology
Published on February 25, 2021
26 min
A selection of talks on Clinical Practice
Transcript
Please wait while the transcript is being prepared...
0:00
My name is Tim Bromage of the New York University College of Dentistry.
In this presentation, I'll provide
further topics within the general theme of hard tissue biology
in human health and evolution.
0:15
There are several aspects of hard tissue biology within the health sciences,
that have been the explicit focus of attention in human evolutionary biology.
These include enamel and tooth biology,
bone biology, craniofacial biology,
and - as the focus in this presentation -
applications in both the medical and human evolutionary sciences
that concern life history and chronobiology.
0:43
Nature abounds with pattern.
One category of patterns is composed of what are called 'recording structures'.
These are typically layers that represent formation over some discrete period of time.
For instance, the annual rings of trees,
tidal variation in seashells,
incremental growth of fish scales and corals,
fish otoliths, mammalian enamel and bone, layers laid down during agate formation,
seasonal layers in sediment microstratigraphy,
and even the macrostratigraphy of sediments.
At all spatial scales from the micron scale of hard tissue increments,
to the kilometer scale of macrostratigraphy,
nature is giving us clues to how things form.
1:33
If you were to section a human incisor tooth along a plane (as shown on the right),
you would see something similar to that of tree rings.
We know that by examining the widths and characteristics of these rings,
we can say something about the life history of that particular tree.
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