- Introduction to Protein Folding and Misfolding
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69 min
- Stability and Kinetics of Protein Folding
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55 min
- Protein Folding Theory
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53 min
- Protein Folding Simulations
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36 min
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42 min
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58 min
- Protein Folding Inside the Cell: Chaperones
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42 min
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34 min
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60 min
- Protein Misfolding and Disease
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44 min
- Protein Design
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33 min
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24 min
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48 min
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44 min
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47 min
- Amyloid Fibrils: Structure, Formation and Nanotechnology
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39 min
- Intrinsically disordered Proteins
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40 min
- Intersection of RNA, translation and protein aggregation.
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47 min
- Proteostasis
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49 min
- Archived Lectures *These may not cover the latest advances in the field
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60 min
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34 min
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41 min
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31 min
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38 min
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49 min
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47 min
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35 min
Topics Covered
- Protein nature, folding and complexity
- Folding in a cellular environment
- The underlying principles of folding
- Native and transition states
- Exploring the energy surface
- The folding of lysozyme
- The consequences of protein misfolding
- The relationship between folding and disease
- Protein deposition diseases
- Protein aggregates in amyloid diseases
- Amyloidogenic mutations of lysozyme
- Mechanism of amyloid formation
- Structure of the amyloidogenic intermediate
- Amyloid formation by lysozyme in vivo
- SH3 domain of PI3 kinase
- Model of an amyloid fibril
- The underlying origins of amyloid disease
- Generic toxicity of amyloid aggregates
- Cellular defences against aggregation
- Evolutionary design of proteins
- "Post-evolutionary" diseases
Links
Series:
Categories:
Talk Citation
Dobson, C. (2007, October 1). Protein folding and misfolding: from theory to therapy [Video file]. In
The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 21, 2023, from
https://hstalks.com/bs/429/.
Export Citation (RIS)
Publication History
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Published on October 1, 2007
Financial Disclosures
- Prof. Christopher Dobson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.