The basal transcription machinery for RNA polymerase II

Published on February 4, 2014   42 min

Other Talks in the Series: Epigenetics, Chromatin, Transcription and Cancer

0:00
My name's Mark Timmers. I've been interested in the process of gene regulation for a very long time, and in doing so, we've gathered a number of insights. I'm going to share with you what we've learned about the basal transcription by RNA polymerase ii.
0:15
But before we go into the details of the basal transcription process itself, it's important to review the elements which are controlling the process of transcription. These are typically, as indicated in orange here, the enhancer sequences which can be located either upstream or downstream or even in the gene, a locus control region which can act over larger distances, and the function of these DNA elements fits into the events that are happening at the start site, indicated by the arrow. And the start site is part of the core promotor sequence, which is surrounding the start site. And it's about only 50 base pairs in total sequence. Although we know that these elements are important from the simple act of looking at the DNA sequences, it's very difficult to find these functional elements.
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The basal transcription machinery for RNA polymerase II

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