Hello, my name is Dr. Giuseppe Ficarra.
I'm the Director of the Reference Center
for the Study of Oral Diseases in Florence.
And this is the second part,
we'll discuss pemphigus vulgaris
which is another fearsome disease.
a group of blistering diseases
of skin and mucosal membrane.
There are several entities
included in the group.
to the action of autoantibodies
directed against transmembrane
which are constituents
of the keratinocytes desmosome.
These molecules are called desmogleins,
their destruction causes
There are several types of pemphigus.
The most common entity is pemphigus vulgaris,
which although a rare disease
can involve the skin and the oral cavity.
Pemphigus foliaceus involves
only the skin
and typically seen in an endemic form
in certain geographic area
such as such South America,
for example, Brazil.
It includes several subtypes.
associated with a neoplastic disease
usually non Hodgkin lymphoma,
it will be discussed in more detail