0:00
My name is Anna Olsson.
I'm a researcher
at the Institute For Research
and Innovation in Health
at University of Porto
in Portugal, the i3S.
And I will be talking to you
today about quality
and validity in animal research.
0:18
So what's the reason to think
about translation,
quality, and validity
of animal research?
Well, one important reason
is that some of your critics
will be thinking about this.
0:33
There is the traditional
criticism
which you may be familiar
with from
some of the anti-vivisection
organizations,
websites, and reports.
That's the criticism which
is based on general arguments
of biological differences
between species.
This is often anecdotal
and not based on systematically
collected data
or in-depth analysis.
And it's published outside
mainstream biomedical
science journals,
often in books or in reports,
or pamphlets
from the organizations
producing the information.
More recently,
over the last 15 years,
a different kind of criticism
has appeared
which is based on meta-analysis
and systematic reviews
of large number of data,
large amounts of data,
and which is published in top
biomedical science journals.
1:28
And if you haven't read
these papers already,
I highly recommend that you'll
look them up after this lecture.
These are two papers published
in two of the top Plos journals,
in Plos medicine we've got,
"Can animal models of disease
reliably inform human studies?"
A pretty provocative question.
And assisted to that study
in Plos biology,
"Publication bias in reports
of animal stroke studies
leads to major
overstatement of efficacy."
These are two papers
which I will come back to,
they come out
of the CAMARADES group
and I will use some of their
results later on in this talk.
The third paper published
in Plos One,
"Survey of the quality
of experimental design,
statistical analysis
and reporting of research
using animals."
If you're familiar
with the Arrive guidelines
and I hope you are,
then this is the paper batch,
led to the publication
of the Arrive guidelines
for how to report research
with animals.
