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Printable Handouts
Navigable Slide Index
- Introduction
- Rheumatoid arthritis (RA)
- Development of rheumatoid arthritis (1)
- Development of rheumatoid arthritis (2)
- Animal models for rheumatoid arthritis
- Collagen-induced arthritis (CIA)
- CIA in DBA/1 mice with non-self type II collagen
- Development of chronic CIA in C57Bl mice
- Development of CIA in mice with black background
- Erosive arthritis in a DBA/1 mouse with CIA (1)
- Erosive arthritis in a DBA/1 mouse with CIA (2)
- Different disease phases of chronic CIA
- CIA model: strengths and weaknesses
- Collagen antibody induced arthritis (CAIA)
- CAIA in BALB/c mice
- Different disease phases of CAIA
- c3 staining in a joint treated with anti-CII antibodies
- Anti-CII antibodies effects
- CAIA model: strengths and weaknesses
- Pristane/mannan induced arthritis
- Pristane-induced arthritis (PIA)
- Pristane induced arthritis development in DA rats
- Pristane induced arthritis induction
- PIA model: strengths and weaknesses
- SKG model of arthritis
- Thymic selection defects in SKG mice
- Mannan-induced psoriasis-arthritis (MIP)
- Mannan induced arthritis
- Performing arthritis experiments
- Choose proper strains
- Compare with or use standard protocol
- High enough number of animals
- Genetically controlled mice/littermates
- Environmentally controlled, mixed in cages
- Balanced experimental groups
- Evaluation - blinded scoring
- Final remarks
Topics Covered
- Rheumatoid arthritis: an overview of development
- Animal models for rheumatoid arthritis
- Performing arthritis experiments
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Holmdahl, R. (2024, July 3). Animal models for rheumatoid arthritis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/WMGK6345.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Rikard Holmdahl has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Animal Models in Biomedical Research
Transcript
Please wait while the transcript is being prepared...
0:00
RIKARD HOLMDAHL:
This material is intended
to describe the use of animal
models for rheumatoid arthritis.
The expected audiences: scientists
in both academia and industry that
want to use animal modeled
for rheumatoid arthritis
for validating drug
treatments or re-investigating
basic mechanisms at
the genesis of arthritis
or basic mechanisms in inflammation.
0:26
To start with, I will review
rheumatoid disease itself,
rheumatoid arthritis
and then go through
with the different available models,
and then have some discussions
on how to best use these models.
So rheumatoid arthritis
is a common disease.
It actually affects 0.5% to
1% of the world population.
It's spread all over the world.
It comes in all ages, and
it is a quite modern disease
actually, a few hundred years old.
And the cause is unknown.
We know it's a chronic disease.
It's lifelong, and it's developed
as an uncontrolled inflammation.
It mainly affects
peripheral joints,
and a typical sign is that it destroys
the joint architecture, cartilage,
and bone.
Also, it has some systemic
manifestation as well.
In particular, in more
severe disease cases.
Importantly, this
is a disease that is
defined with a certain set of criteria
of different symptoms and signs.
And it's probably
more proper to call it
a syndrome with a
number of different,
so far undefined subtypes.
This is of course important
considering animal models
since animal models are by
definition, something we create
ourselves, and it's more defined.
So it might only represent
subtypes of rheumatoid arthritis,