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Improving and humanizing animal models by microbiomic techniques
Published on February 11, 2015 42 min
Other Talks in the Series: Animal Models in Biomedical Research
Creating animal models by genetic techniques
- Mr. Emmanuel Gomas
- Transgenic Technologies Training and Consulting, 3TC, France
Surgical models and perioperative care in swine
- Prof. M. Michael Swindle,
- Prof. Mary Ann McCrackin
Animal models of seizures and epilepsy
- Dr. Wolfgang Löscher
- University of Veterinary Medicine, Germany
Hello, my name is Axel Kornerup Hansen. I'm a professor and the board chairman of science at the University of Copenhagen. In this lecture, I will introduce you to the impact that the microbiome has on animal models, and how we can improve your work with these models by considering these aspects. In principle, this could be about models in various species. But I will focus on rodents, because they outnumber other model species, because there are those who are primarily used for their low variation, and high potential for standardisation, and also because this is what I'm actually working with in my own research group.
In this lecture, I will start out by talking about how bacteriological monitoring is done in laboratory rodents today. And after that, I will introduce to the fascinating world of the gut microbiota. I will talk about the impact that this microbiota has in rodent models, and give a short and very incomplete impression on how this interaction between the host and the microbiota may take place. And introduce you to how much variation actually causes in your rodent models, and I will end up presenting some plausible ways to deal with this impact.
Bacteria are a source of variation in laboratory animal work. This is not a new issue, and the systematic handling of the variation caused by bacteria has developed from the beginning of the 20th century, through the millennium, and up till today. However, there's still much which can be done. So let me start out by shedding a critical light on the states at which we are today in laboratory animal breeders, be it facilities, or be it scientists.