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Development of immunotherapies for type 1 diabetes. Value and limitations of mouse models.

Published on February 11, 2015   40 min

A selection of talks on Cardiovascular & Metabolic

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0:00
Hello, everybody. I'm Matthias von Herrath, and I'm a professor at La Jolla Institute, and also a vice present for Novo Nordisk for an approach that develops therapeutics for type 1 diabetes. We'll be talking about the value and limitation of mouse models in general today, but I will construct the talk with an area that I know best, which is the development of immune therapies for type 1 diabetes. And these examples I will give you in the course of the talk should hopefully also be very useful for the use of animal models in other therapeutic areas.
0:45
It's a timely situation because, especially in diabetes, but also in other applications of biology, there has always been a lot of controversy surrounding the use of animal models, whether they reflect the human situation, whether they don't reflect the human situation, when they reflect the human situation. And really, what you will see from the talk, and as my position on this whole subject, is that it's very valuable to use animal models, and in this case mouse models, which we will be talking about today, if they are used in the correct fashion. And hopefully from the ensuing talk, you can gather some advice on how this can be done, and also to realize that it's very important in the design of experiments and in the whole translation of the process from animal models to the human bedside to know the limitation of such animal models. I should also add that I will not discuss, because I also work for a pharmaceutical company, Novo Nordisk, I will not discuss any drugs or approaches from Novo Nordisk that are specific for the company, and that will be my disclaimer.

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Development of immunotherapies for type 1 diabetes. Value and limitations of mouse models.

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