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              Printable Handouts
Navigable Slide Index
- Introduction
 - Overview
 - Sjogren’s disease (1)
 - Sjogren’s disease (2)
 - Sjogren’s associations
 - Epidemiology (1)
 - Epidemiology (2)
 - Incidence
 - Etiology and pathogenesis (1)
 - Etiology and pathogenesis (2)
 - Pathogenesis: innate and adaptive immunity
 - Pathogenesis: auto-antibodies
 - SSA (Ro) & SSB (La) disease associated Ab's
 - Pathogenesis: role of immune complexes
 - Pathogenesis: cytokines
 - Genetics
 - Etiology and pathogenesis: more data
 - Neuro - immune interface
 - Channelopathies
 - Exocrine gland dysfunction
 - Diagnosis
 - Classification criteria
 - Early detection
 
Topics Covered
- Sjogren's disease: epidemiology
 - Incidence
 - Etiology & pathogenesis
 - Genetics
 - The neuro-immune interface
 - Channelopathies
 - Exocrine gland dysfunction
 - Diagnosis
 - Classification criteria
 - Detection
 
Talk Citation
Carteron, N. (2016, October 31). Sjogren’s disease - epidemiology, etiology, pathogenesis & diagnosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 4, 2025, from https://doi.org/10.69645/MMCF2725.Export Citation (RIS)
Publication History
Financial Disclosures
- The speaker is a member of the DMC for Bristol Myers Squibb and a medical reviewer and consultant for Healthline.
 
Sjogren’s disease - epidemiology, etiology, pathogenesis & diagnosis
A selection of talks on Immunology & Inflammation
Transcript
Please wait while the transcript is being prepared...
      
      
        
                  0:00
                
                
                  
                    My name is Nancy Carteron.
                  
                    I'm a Scientist
in San Francisco.
                  
                    I'm a Senior Consultant
in Rheumatology and Immunology
                  
                    and an Associate
Clinical Professor
                  
                    at University California
San Francisco,
                  
                    here in San Francisco.
                  
                    Today we're gonna talk about
Sjogren's disease.
                  
                
              
                  0:22
                
                
                  
                    The topics that I would like
to cover include briefly,
                  
                    introducing the topic,
moving onto epidemiology.
                  
                    Then we'll focus on etiology
and pathogenesis,
                  
                    moving on to symptoms
and signs of the disease,
                  
                    followed by diagnosis.
                  
                    We'll touch
on some treatment options.
                  
                    And briefly conclude
with some information
                  
                    on the prognosis of the disease.
                  
                
              
                  0:50
                
                
                  
                    So Sjogren's is
a serious autoimmune disease.
                  
                    It was first described
by Henrik Sjogren in 1933,
                  
                    who was an ophthalmologist.
                  
                    And even from the first reports,
                  
                    the hallmark,
which maintains true to today,
                  
                    is an infiltration
of target exocrine glands
                  
                    by lymphocytes.
                  
                    These lymphocytes can infiltrate
a wide range of glands
                  
                    and target organs
not just the exocrine glands.
                  
                    And this can include skin,
lung, gastrointestinal,
                  
                    nervous system tissue,
particularly the ganglia.
                  
                    Sjogren's can occur alone
                  
                    and then is referred
to as primary Sjogren's
                  
                    or concomitant with
another autoimmune disease,
                  
                    then referred
to as secondary Sjogren's.
                  
                    Examples of these
other autoimmune diseases
                  
                    that commonly can co-associate
                  
                    with Sjogren's
are rheumatoid arthritis,
                  
                    primary biliary cirrhosis,
and lupus.