We noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Genetics of cancer
- Oncogenes
- Tumor suppressor genes
- Breast cancer "family 0"
- The two-hit hypothesis
- How much breast and ovarian cancer is hereditary
- Hereditary susceptibility causes to ovarian cancer
- Hereditary susceptibility causes to breast cancer
- BRCA1 and BRCA2 mutations
- Lifetime cancer risk in mutation carriers
- Epidemiology: BRCA1 and BRCA2
- Founder effect
- Selected examples of founder mutations
- BRCA1 and BRCA2 mutations in Ashkenazi Jews
- Varied penetrance
- New York breast cancer study (NYBCS)
- NYBCS family 96: "low incidence family"
- Family 96: BRCA1 5382insC
- Relatives with BRCA1\2 mutations: breast cancer
- Relatives with BRCA1\2 mutations: ovarian cancer
- Relatives with BRCA1\2 mutations: cancer onset
- Factors affecting penetrance
- Factors not significantly associated with age
- New York breast cancer study conclusions
- Mutation detection for BRCA1 and BRCA2
- Inherited large rearrangements in BRCA1\BRCA2
- Genomic regions of BRCA1 and BRCA2
- Genetics of breast cancer "mystery families"
- Inherited breast and ovarian cancer
- PALB2 1592delT in Finnish breast cancer families
- PALB2 1592delT: Finnish prostrate cancer family
- Genes for inherited breast cancer
- Breast cancer genes and genomic integrity
- Biology of breast cancer genes
- Identification of inherited cancer risk
- Benefits
- Risk assessment
- Cancer risk reduction in women
- Preventive removal of ovaries
- Women with increased-risk family history
Topics Covered
- General cancer genetics
- Tumor suppressor and oncogenes
- Knudson's 'two hit' hypothesis
- Genetic predisposition to breast and ovarian cancer
- How much breast and ovarian cancer is inherited and the causes (genes responsible)
- Cancer risk in populations
- Factors that affect penetrance
- Mutation detection
- Risk reduction and prevention strategies
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Welcsh, P. (2007, October 1). The genetics of breast and ovarian cancer [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/XVCX9892.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Piri Welcsh has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.