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Oncolytic viruses: strategies, applications and challenges

Published on September 28, 2023   48 min

Other Talks in the Series: Gene Transfer and Gene Therapy

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0:00
Hi, I'm Stephen Russell, CEO of Vyriad. The title of my talk today is Oncolytic Viruses Strategies, Applications and Challenges.
0:17
By way of disclosure, I am a co founder, shareholder, and the CEO of Vyriad which is a company developing and commercializing targeted genetic medicines including oncolytic virus therapies.
0:32
Let's get into oncolytic virus therapy. This slide illustrates the two stage model of oncolytic virus therapy in which the virus infects the tumor spreads locally and causes tube cell killing with release of tumor antigens which in turn are picked up by the immune system and drive the amplification of the anti tumor immune response which brings about longer term control of distant, uninfected tumors.
1:06
Virtually any virus can theoretically be adapted or engineered to be an effective oncolytic agent. There is a vast universe of different viruses out there with DNA or RNA genomes with single or double stranded nucleic acid encapsidated and with in the case of RNA viruses, positive sense or negative sense RNA genomes. This is truly a vast untapped bio resource for future development in the field of oncolytic virus therapy.
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Oncolytic viruses: strategies, applications and challenges

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