Hi. My name is Dr. Pardo,
a team leader at the Division of Cancer at Imperial College
and today I'm going to tell you about the biology of cancer.
This is a basic lecture on cancer biology,
so this is not going to go extensively
through all the subjects relating to cancer biology,
but just introduce some notion that I hope you will find interesting.
So, what exactly shall we touch upon in this lecture?
The first thing that I have to say is that we are assuming
here that you already know about cancer as a disease,
meaning what is cancer versus other diseases.
Therefore, what we're going to more specifically focus on here, today, is to present
general hallmarks of cancer and
explain how these phenotypes relate to cancer development,
explain, also, how cancer is initiated through activations of particular genes
called oncogenes and deactivation of antioncogenes called tumor suppressors.
We're going to also explain what makes this gene so special as
compared to antioncogenes in the genome and show
the different ways that cancer cells use to
rewire cell signaling in order to promote tumor development.
Also, I will introduce the idea that a tumor is not only
about the cancer cell, but also about the microenvironment-
what surrounds the tumor.
Finally, I'm going to give you examples on not only how we use
this knowledge to develop new therapeutic strategies,
but also what the challenges are in current therapy development.