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Now I'd like to switch gears and
address another novel concept that
has originated based on
work in our laboratory.
The basic premise here is that some
elements of inducible wound healing
is actually retained in the adult
skin tissue in a silenced form.
This silencing is primarily
executed by microRNA.
As one example, we have
discovered that miR-200b in skin,
microvascular endothelial cells,
act as an angiostatic agent
This silencer is
wound angiogenesis to start.
Let's look at the data here.
In Panel A, you see human
microvascular dermal endothelial
cells, a scratch assay
has been done to study
the migration of these cells.
And if you added miR-200b
mimic to these cells
you clearly blunt or decelerate
the migration of the cells
across the scratch.
In Panel B, it is shown that
the ability of these cells
to from tubes in a matrigel, which
is a sign of angiogenic property,
such angiogenic property is
remarkably blunted or impaired
in the presence of miR-200b mimic.
Supporting the notion that miR-200b
has potent angiostatic properties.