Botchkarev, V. (2014, November 4). Skin epigenetics: how chromatin regulators orchestrate skin functions [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 4, 2024, from https://hstalks.com/bs/2833/.
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Published on November 4, 2014
Prof. Vladimir Botchkarev has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
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Hello.My name is Vladimir Botchkareve and
I'm professor of cutaneous biologyin Center of Skin Sciences
at University of Bradford.And I'm also keeping adjunct
professorship in Departmentof Dermatology and Pathology
in Boston University in the US.The topic of my lecture is skin
epigenetics or the story on howchromatin regulators
orchestrate skin functions.
Skin is the largest organ of the
body that operates as interfacebetween the external
environment and internal media.Skin consists of two embriologically
distinct layers, epidermisderived from the ectoderm
and dermis with subcutisderived from the
mesoderm, or mesenchyme.Skin also contains a
number of skin appendages,including hair follicles
and sweat glands.
Skin fulfills a number of vitally
important functions, includingprotection against
environmental stressors,maintenance of body
temperature and water balance,transmission of sensory information,
endocrine and immune functions,and also visual appearance and
development, multipotentstem cells establish distinct
programs of gene expressionunderlying their differentiation
into distinct types of skinappendages, such as hair follicles,
nails, or ectodermal glands.In other words, the same
genome in multipotentstem cell has to be reorganized
towards establishingdistinct lineage specific patterns
of gene activation and silencing,or maybe transcriptional
bar codes to achievestructural and functional
diversity in differentiated cells.