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Printable Handouts
Navigable Slide Index
- Introduction
- Skin structure
- Functions of the skin
- Skin development
- Molecular control of cell differentiation
- BMP signaling and BMP antagonist Noggin
- What is epigenetics?
- What controls variability of skin phenotypes?
- Chromatin is a DNA-protein complex
- Genes encoding keratinocyte-specific proteins
- Molecular signature of epidermal layers
- Levels of epigenetic regulation
- DNA methylation and hydroxymethylation
- Methylation status regulates coat color
- DNA methylation influence on the epidermis
- Post-translational histone modifications
- Post-translational covalent modifications
- Histone acetylation/de-acetylation
- Polycomb-repressive complex
- Polycomb-dependent H3K27 methylation
- Polycomb and Trithorax play antagonistic roles
- ATP-dependent chromatin remodeling
- Remodeling during epidermal barrier formation
- Formation “active” or “repressed” states
- Non-coding RNA-dependent mechanisms
- Non-coding RNAs are essential elements
- Higher-order chromatin remodeling
- Nucleus: storage, replication of genetic material
- Nuclear architecture is markedly re-organized
- Chromosomes occupy distinct territories
- Topological gene interactomes
- Interactomes and their role in coordination
- Morphogenesis of the epidermis
- Epidermal differentiation complex
- Relocation from the peripheral to internal part
- EDC and Lor relocation to nuclear interior
- p63 -/- skin epithelium alters gene expression
- p63 directly regulates Brg1 and Satb1
- p63 and Brg1 ablation results in retention of EDC
- Brg1 binds to the EDC genes
- Genome organizer AT-rich binding Satb1 protein
- AT-rich binding protein Satb1
- Genetic Satb1 ablation
- Transcription factor and epigenetic mechanisms
- Future directions of epigenetic research
Topics Covered
- Skin structure, functions and development
- Molecular control of cell differentiation
- What is epigenetics?
- What controls variability of skin phenotypes?
- Genes encoding keratinocyte-specific proteins
- Molecular signature of epidermal layers
- Levels of epigenetic regulation
- DNA methylation and hydroxymethylation
- DNA methylation influence on the epidermis
- Post-translational histone/covalent modifications
- Histone acetylation/de-acetylation
- Polycomb-repressive complex
- Polycomb and Trithorax play antagonistic roles
- ATP-dependent chromatin remodeling
- Non-coding RNA-dependent mechanisms
- Nucleus: storage, replication of genetic material
- Topological gene interactomes
- Morphogenesis of the epidermis
- Epidermal differentiation complex
- EDC and Lor relocation to nuclear interior
- p63 and Brg1 ablation results in retention of EDC
- Genome organizer AT-rich binding Satb1 protein
- Transcription factor and epigenetic mechanisms
- Future directions of epigenetic research
Talk Citation
Botchkarev, V. (2014, November 4). Skin epigenetics: how chromatin regulators orchestrate skin functions [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 7, 2024, from https://doi.org/10.69645/JJPB4873.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Vladimir Botchkarev has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Dermatology
Transcript
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0:00
Hello.
My name is Vladimir Botchkareve and
I'm professor of cutaneous biology
in Center of Skin Sciences
at University of Bradford.
And I'm also keeping adjunct
professorship in Department
of Dermatology and Pathology
in Boston University in the US.
The topic of my lecture is skin
epigenetics or the story on how
chromatin regulators
orchestrate skin functions.
0:27
Skin is the largest organ of the
body that operates as interface
between the external
environment and internal media.
Skin consists of two embriologically
distinct layers, epidermis
derived from the ectoderm
and dermis with subcutis
derived from the
mesoderm, or mesenchyme.
Skin also contains a
number of skin appendages,
including hair follicles
and sweat glands.
0:55
Skin fulfills a number of vitally
important functions, including
protection against
environmental stressors,
maintenance of body
temperature and water balance,
transmission of sensory information,
endocrine and immune functions,
and also visual appearance and
psychosocial communications.
1:17
During ectodermal
development, multipotent
stem cells establish distinct
programs of gene expression
underlying their differentiation
into distinct types of skin
appendages, such as hair follicles,
nails, or ectodermal glands.
In other words, the same
genome in multipotent
stem cell has to be reorganized
towards establishing
distinct lineage specific patterns
of gene activation and silencing,
or maybe transcriptional
bar codes to achieve
structural and functional
diversity in differentiated cells.
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