Skin epigenetics: how chromatin regulators orchestrate skin functions

Published on November 4, 2014   33 min
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Hello. My name is Vladimir Botchkareve and I'm professor of cutaneous biology in Center of Skin Sciences at University of Bradford. And I'm also keeping adjunct professorship in Department of Dermatology and Pathology in Boston University in the US. The topic of my lecture is skin epigenetics or the story on how chromatin regulators orchestrate skin functions.
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Skin is the largest organ of the body that operates as interface between the external environment and internal media. Skin consists of two embriologically distinct layers, epidermis derived from the ectoderm and dermis with subcutis derived from the mesoderm, or mesenchyme. Skin also contains a number of skin appendages, including hair follicles and sweat glands.
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Skin fulfills a number of vitally important functions, including protection against environmental stressors, maintenance of body temperature and water balance, transmission of sensory information, endocrine and immune functions, and also visual appearance and psychosocial communications.
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During ectodermal development, multipotent stem cells establish distinct programs of gene expression underlying their differentiation into distinct types of skin appendages, such as hair follicles, nails, or ectodermal glands. In other words, the same genome in multipotent stem cell has to be reorganized towards establishing distinct lineage specific patterns of gene activation and silencing, or maybe transcriptional bar codes to achieve structural and functional diversity in differentiated cells.
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Skin epigenetics: how chromatin regulators orchestrate skin functions

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