0:00
Hello.
My name is Vladimir Botchkareve and
I'm professor of cutaneous biology
in Center of Skin Sciences
at University of Bradford.
And I'm also keeping adjunct
professorship in Department
of Dermatology and Pathology
in Boston University in the US.
The topic of my lecture is skin
epigenetics or the story on how
chromatin regulators
orchestrate skin functions.
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Skin is the largest organ of the
body that operates as interface
between the external
environment and internal media.
Skin consists of two embriologically
distinct layers, epidermis
derived from the ectoderm
and dermis with subcutis
derived from the
mesoderm, or mesenchyme.
Skin also contains a
number of skin appendages,
including hair follicles
and sweat glands.
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Skin fulfills a number of vitally
important functions, including
protection against
environmental stressors,
maintenance of body
temperature and water balance,
transmission of sensory information,
endocrine and immune functions,
and also visual appearance and
psychosocial communications.
1:17
During ectodermal
development, multipotent
stem cells establish distinct
programs of gene expression
underlying their differentiation
into distinct types of skin
appendages, such as hair follicles,
nails, or ectodermal glands.
In other words, the same
genome in multipotent
stem cell has to be reorganized
towards establishing
distinct lineage specific patterns
of gene activation and silencing,
or maybe transcriptional
bar codes to achieve
structural and functional
diversity in differentiated cells.
