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Printable Handouts
Navigable Slide Index
- Canine atopic dermatitis
- Introduction
- Pathogenesis
- Pathogenesis - environmental factors
- Pathogenesis - skin barrier defects
- Pathogenesis - allergic sensitisation
- Pathogenesis - microbial colonisation
- Pathogenesis - microbiome
- Pathogenesis - immune dysregulation
- Pathogenesis - lipid metabolism abnormalities
- Diagnosis
- Diagnosis - general & dermatological history
- Diagnosis - history – breed predisposition
- Diagnosis - clinical features
- Diagnosis - clinical features: facial lesions
- Diagnosis - clinical features: foot & leg lesions
- Diagnosis - other clinical features
- Diagnosis - clinical features
- Diagnosis - elimination of differentials (1)
- Diagnosis - elimination of differentials (2)
- Diagnosis - elimination of differentials (3)
- Diagnosis - tape strip procedure
- Diagnosis - adverse cutaneous food reaction
- Diagnosis - allergy testing (1)
- Diagnosis - allergy testing - intradermal testing
- Diagnosis - allergy testing (2)
- Management
- Management - ICADA
- Management - acute flares (1)
- Management - avoidance of acute flares
- Management - acute flares (2)
- Management - Malassezia dermatitis
- Management - skin & coat hygiene
- Management - topical glucocorticoids
- Management - oral Oclacitinib
- Management - Lokivetmab
- Management - avoidance of chronic flares
- Management - non-irritating shampoo
- Management - omega 3 &6
- Management - pruritus pharmacological agents
- Management - recurrence of clinical signs
- Summary
Topics Covered
- Environmental factors that can affect the pathogenesis
- Association between the microbiome and CAD
- Immune dysregulation as an influential factor
- A history and clinical features of CAD
- How to eliminate differentials
- Allergy testing for specific allergens
- Flare factors and how to avoid them
- Pharmacological treatment options
Links
Categories:
Therapeutic Areas:
Talk Citation
Craig, M. (2019, June 30). Canine atopic dermatitis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 9, 2024, from https://doi.org/10.69645/GLKT1278.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Mark Craig has no commercial/financial relationships to disclose
A selection of talks on Clinical Practice
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is Mark Craig.
I'm a veterinary dermatologist.
In 1993, I founded Re-Fur-All Referrals,
a veterinary dermatology referral service in the South of England,
the Midlands, and Wales.
I'm particularly interested in skin allergies.
I'm fascinated by the explosion of scientific research on the association of
the intestinal microbiota with the immune system and an enormous range of diseases.
Today, I'm going to present an overview of "Canine Atopic Dermatitis",
one of the commonest
yet most poorly understood disorders seen in small animal veterinary practice.
0:38
Canine atopic dermatitis, CAD,
is currently defined as a genetically predisposed,
inflammatory and pruritic allergic skin disease with
characteristic clinical features associated with IgE,
most commonly directed against environmental allergens.
It's very common, though its true prevalence in the canine population
is unknown and often very challenging and frustrating to treat.
1:06
The pathogenesis is multifactorial,
extremely complex and incompletely understood.
Genomic studies have unearthed numerous genes
probably involved via their effects on immunity,
skin barrier formation, apoptosis and inflammation.
There does appear to be a hereditary predisposition,
but no one gene is responsible.
There's a strong breed predilection with Golden Retrievers,
West Harlem White Terriers,
German Shepherd dogs, Cocker Spaniels,
Boxers, and French bulldogs commonly affected.
However, this breed predilection varies throughout the world,
and different genetic mutations may be
relevant to different breeds in specific geographical areas.
Genetic interactions are extraordinarily complex.
So even with the advent of
new genetic technologies such as genome-wide association studies,
it's unlikely that screening and breeding programs,
for example, could ever be successful in eliminating atopic dermatitis.
However, these new technologies may allow us to develop new more targeted therapies.