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Printable Handouts
Navigable Slide Index
- Introduction
- Atopic eczema and eczema variants
- Atopic eczema
- Epidemiology of AE
- Atopic eczema impairs ability to work
- Atopic eczema impact on mental health
- Atopic eczema: disease course
- Diagnostic criteria & clinical features
- Atopic eczema: Hanifin and Rajika criteria
- Atopic/non-atopic, extrinsic/intrinsic eczema
- Atopic eczema: criteria
- Atopic eczema in adults
- Atopic eczema in infants
- Severe atopic eczema
- Appearance of atopic eczema
- Complications of atopic eczema
- Staphylococcal super-infection
- Eczema herpeticum
- Trigger factors
- AE microbial diversity
- Food allergy
- Cochrane review
- Egg exclusion diet vs. general advice
- DBPCFC in children with AE
- Cochrane review: possible conclusions
- The message
- Allergic co-morbidities
- Allergic march
- Challenges to allergic march concept
- Pathophysiology
- Epidermal barrier function in AE
- Genetics
- GWAS – atopic eczema
- Fillaggrin common loss of function variants
- Filaggrin
- Environment
- Postnatal antibiotic exposure and eczema risk
- The immune system is important for AE
- IgE
- T cells in AE pathogenesis
- T cells are central to pathogenesis
- Why Th2 responses:
- Changing immunophenotype
- Immune responses overview
- Immune responses: summary
- Current treatment
- Aetiology of atopic eczema
- What causes atopic eczema?
- Emollients
- Clothing/bandages
- Topical steroids
- Topical steroid side effects
- Calcineurin inhibitors
- Targeting microbes in AE
- Treatment flowchart
- Future treatment
- Filaggrin copy number – affects expression levels
- Restoration of filaggrin status
- Coal tar up-regulates filaggrin expression
- Preventing complications from barrier function loss
- Anti-Th2?
- CRTH2 inhibitors
- Many roads lead to Rome
- Atopic eczema remains a complex disease
- We need to use biomarkers in trials
- Conclusions
Topics Covered
- Atopic eczema and eczema variants (epidemiology and impact of AE)
- Diagnostic criteria & clinical features
- Complications of atopic eczema
- Trigger factors
- Allergic co morbidities
- Pathophysiology
- Current treatment
- Future treatment
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Ardern-Jones, M. (2016, September 29). Atopic eczema/atopic dermatitis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved February 19, 2019, from https://hstalks.com/bs/3348/.Publication History
Atopic eczema/atopic dermatitis
Published on September 29, 2016
49 min
Other Talks in the Series: Skin Biology
Transcript
0:00
Hello, I'm Michael Ardern-Jones,
Associate Professor
of Dermatology
and Clinical Consultant
Dermatologist
at the University
of Southampton.
And today I'm going to talk to you
about Atopic Eczema.
In this title slide reminds me
to have emphasize
that the term Atopic Eczema
is synonymous
with the Atopic Dermatitis.
The two are completely
interchangeable
and if I use atopic eczema
throughout subsequent slides
then you could also replace that
with atopic dermatitis.
0:28
Atopic eczema is one of variety
of different eczemas
and I've listed here some
different variants of eczema
which I'm not going to focus
on this presentation,
instead I'm going to talk
about atopic eczema
which is characterized
by an itchy,
chronically relapsing,
inflammatory skin condition
that is much more prominent
in childhood than in adulthood.
0:50
I'm going to talk to you
about epidemiology,
diagnostic criteria
and clinical features,
co-morbidities, genetics, immunology,
allergy and current management,
and then I'm going to move on
to future management
of the disease.
1:05
Epidemiology
of atopic dermatitis
has been studied for a long time
and one of the most
important studies
has been the international study
on asthma and allergy in childhood
which looked at the prevalence
of allergies,
including eczema,
in 106 countries.
And this study
was able to undertake
a global prevalence measurement
of atopic eczema
and you can see here
that although there was
a wide range of prevalence
in atopic eczema
in different countries
that actually
this is a common disease
in children.
The UK as you can see it
lies at the upper end
of the prevalence range
and this is reflected
in the health demands
in our country.
A recent systematic review
of prevalence studies
has shown that
lifetime prevalence
of atopic eczema
is approximately 20%
in Western countries
and that this is in fact
increasing year on year.
A recent study looked
at the prevalence
in different age groups
of children
and you can see here
how majority of atopic eczema
arises in the first year
of life.
Adults atopic eczema
is far less common
and affects one to three
percent of adults.