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Printable Handouts
Navigable Slide Index
- Introduction
- Talk overview
- Neuronal structure and function in healthy skin
- Myelinated fibers
- Myelinated fibers: functional significance
- Unmyelinated or thinly myelinated fibers
- Myelinated vs. unmyelinated fibers
- Epidermal free nerve endings
- Sensors for thermoregulation
- Nociceptors detect threats
- Mechano-heat sensitive nociceptors
- Mechano-insensitive chemo-nociceptors
- Cold nociceptors
- Pruriceptors
- Classification of nociceptors
- Functional classes of nociceptors
- Recent advances in itch mechanisms
- C-touch fibers: pleasant touch (1)
- C-touch fibers: pleasant touch (2)
- Efferent sympathetic innervation of the skin
- Functional tests of small fibers
- Small fiber neuropathy
- Epidermal innervation and sensory function
- Increased & decreased innervation (1)
- Epidermal innervation and chronic pain
- Increased & decreased innervation (2)
- Additional neuronal functions in the skin
- Neurogenic inflammation
- Neurogenic inflammation: dermal microdialysis
- No protein extravasation in healthy human skin
- Neuropeptide-induced vasodilation
- SP induced extravasation and vasodilation
- SP but not CGRP induces histamine release
- Neurogenic inflammation: summary
- Keratinocytes-nerve endings communication (1)
- Keratinocytes-nerve endings communication (2)
- Interaction between neurons and skin cells
- Innervation of air-exposed skin equivalent
- Nerve neuropeptides increase epidermal growth
- Keratinocytes from atopic dermatitis patients
- Mechanisms of nociceptor sensitization
- Talk summary
Topics Covered
- Physiology of skin senses
- Touch, temperature, itch and pain
- Crosstalk between neurons and keratinocytes
- Neuronal sensitization as basis for chronic itch and pain
Links
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Therapeutic Areas:
Talk Citation
Schmelz, M. (2014, October 7). Skin innervation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/BKOY4783.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Martin Schmelz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Neuroscience
Transcript
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0:00
Welcome to this
presentation on skin innervation.
My name is Martin Schmelz.
I'm a neurophysiologist, and having
worked mainly on pain and itch.
0:13
In this presentation,
we will first focus
on structure and sensory
function in healthy skin
and then switch to skin innervation
changes that happen in disease,
such as loss of innervation
for polyneuropathy
and increased innervation that may
be found in chronic itch and pain.
And finally, we will also
touch upon neuronal function
beyond sensory tasks.
0:41
When we regard innervation
of healthy skin,
the most abundant nerve fibers are
small nerve fibers with free nerve
endings that innervate
the dermis, and are
particularly dense in the epidermis.
In contrast, these
thick nerve fibers
have specific sensory endings
such as the Pacinian corpuscles
and the Meissner corpuscles,
located in the dermis.
1:09
The myelinated fibers are low
threshold mechanosensitive fibers
that are important to
detect touch and texture.
They can be differentiated into
superficial and deeply located
ones, with the superficial
ones having small innervation
territories and deep ones,
large innervation territories.
Merkel and Ruffini endings are
slowly adapting, meaning that they
encode chronic stimuli, whereas
Meissner receptors and Pacinian
corpuscles are rapidly
adapting, such that they
are particularly sensitive
to phasic simulation.