0:00
My topic
today is to speak about vitiligo.
And I'm going to present some
in vivo and in vitro evidence
of epidermal Reactive Oxygen
Species and Reactive Nitrogen
Species-mediated regulation
or dysregulation in this disease.
0:15
The vitiligo is affecting,
of course, mostly the skin.
And since the skin is the largest,
outer-most organ of the human body,
it has an approximate size
of 1.85 to 2 square meter.
It's responsible for the
protection of our human body
against many environmental stress;
for example, radicals, chemicals,
heat, cold, water, and so on.
So I'm going to explain on the next
slide how the layers of the skin
is actually composed, especially
about the epidermal part
of the skin.
0:52
The outermost layer is composed
of the epidermis and the dermis
and subcutis, as seen
in this slide here.
The majority of the epidermis
is constructed of keratinocytes.
This is the melanocytes
at the basement membrane.
One melanocyte is surrounded
by 36 keratinocytes
and forming the
so-called epidermal unit.
At the basement membrane, and
we have the stratum basale.
That's the proliferation
zone of the epidermis,
followed by the stratum spinosum
and then the stratum corneum.
And those are the parts we
are interested in right now.
1:29
Now our skin color, that
what we are born with,
we call it the inherited skin color.
And then of course, we can also
use tanning to adjust the skin
color by, for example,
solar exposure.
