0:00
I want to welcome you
to this presentation.
My name is Kenji Kabashima.
I'm an associate professor of the
Department of Dermatology, Kyoto
University Graduate School
of Medicine, Kyoto, Japan.
In this lecture, I'd like to
discuss the skin immune status
in the perspective of live imaging
of the skin in three dimensions.
0:25
In this lecture, I
would like to talk
on four topics: immune
response in the skin,
live imaging of the
skin in three dimensions,
immune response to haptens,
and immune response
to protein antigens.
First of all, I will talk on
the overview of immune response
in the skin.
0:47
This is an immunohistochemical
staining of the skin,
with S100 protein, which illustrates
epidermal Langerhans cells.
There are about 1,000
Langerhans cells
per square millimeter
in the epidermis.
Since Langerhans cells function
as antigen presenting cells
in the skin, this
histological finding
implies that the skin
is an immune organ.
1:16
The skin is exposed to a
variety of external stimuli,
including physical stress, dryness,
ultraviolet light exposure,
bacteria, fungus, virus,
parasite infection, haptens,
metals, chemicals,
and protein antigens.
1:37
As a result of immune
responses to external stimuli,
the skin exhibits a
variety of skin diseases,
including urticaria to egg and fish
taken orally, contact to dermatitis
to metal, urushiol, atopic
dermatitis to mite, dust, pollen,
and psoriasis vulgaris to possible
self antigens or self DNA.
