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Skin immune status - live imaging of the skin in 3D
Published on May 4, 2014 33 min
Other Talks in the Series: Skin Biology
Skin epigenetics: how chromatin regulators orchestrate skin functions
- Prof. Vladimir Botchkarev
- University of Bradford, UK
The epidermis and its barrier(s)
- Dr. Gopinathan Menon
- California Academy of Sciences, California, USA
I want to welcome you to this presentation. My name is Kenji Kabashima. I'm an associate professor of the Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan. In this lecture, I'd like to discuss the skin immune status in the perspective of live imaging of the skin in three dimensions.
In this lecture, I would like to talk on four topics: immune response in the skin, live imaging of the skin in three dimensions, immune response to haptens, and immune response to protein antigens. First of all, I will talk on the overview of immune response in the skin.
This is an immunohistochemical staining of the skin, with S100 protein, which illustrates epidermal Langerhans cells. There are about 1,000 Langerhans cells per square millimeter in the epidermis. Since Langerhans cells function as antigen presenting cells in the skin, this histological finding implies that the skin is an immune organ.
The skin is exposed to a variety of external stimuli, including physical stress, dryness, ultraviolet light exposure, bacteria, fungus, virus, parasite infection, haptens, metals, chemicals, and protein antigens.
As a result of immune responses to external stimuli, the skin exhibits a variety of skin diseases, including urticaria to egg and fish taken orally, contact to dermatitis to metal, urushiol, atopic dermatitis to mite, dust, pollen, and psoriasis vulgaris to possible self antigens or self DNA.