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- Introduction to Calcium Signaling
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72 min
1. Introduction to cellular calcium signaling- Dr. Martin Bootman
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20 min
2. Monitoring Ca2+ concentration in living cells- Dr. Marisa Brini
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30 min
3. Cell boundary theorem- Prof. Eduardo Ríos
- Calcium Influx
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19 min
4. Arachidonic acid and store-independent Ca2+ entry- Dr. Luca Munaron
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34 min
5. Voltage-dependent calcium channels- Prof. Annette Dolphin
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34 min
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37 min
7. Intracellular Ca2+ signaling: calcium influx- Prof. Anant Parekh
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60 min
8. Molecular identification of the CRAC channel- Prof. Michael Cahalan
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35 min
- Calcium Release
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47 min
10. The molecular biology of the inositol trisphosphate receptor- Dr. Randen Patterson
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53 min
11. The InsP3 receptor calcium release channel- Prof. J. Kevin Foskett
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31 min
12. Molecular biology of ryanodine receptors- Dr. Christopher George
- Prof. F. Anthony Lai
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57 min
13. cADPR and NAADP: messengers for calcium signalling- Prof. Antony Galione
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50 min
14. Coordinated Ca2+ release from intracellular Ca2+ stores- Prof. Ole Petersen
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43 min
15. Ryanodine receptors and cardiac function- Prof. David Eisner
- Calcium Efflux and Sequestration
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45 min
16. The plasma membrane calcium pump: biochemistry, physiology and molecular pathology- Prof. Ernesto Carafoli
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60 min
17. The calcium saga: a matter of life and death- Prof. Pierluigi Nicotera
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45 min
18. Sodium-calcium exchange- Prof. John Reeves
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22 min
19. Ca2+ efflux and Ca2+ signals- Dr. Anne Green
- Organelle Calcium
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42 min
20. Regulation and role of mitochondrial Ca2+ homeostasis- Prof. Rosario Rizzuto
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54 min
21. Peroxisomes and Golgi apparatus as players in Ca2+ homeostasis- Dr. Paola Pizzo
- Dr. Alex Costa
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31 min
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34 min
23. Ca2+ dynamics between mitochondria and the endoplasmic reticulum- Dr. Wolfgang Graier
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26 min
24. Nuclear calcium signaling- Dr. Oleg Gerasimenko
- Dr. Julia Gerasimenko
- Spatiotemporal Calcium Signals
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58 min
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54 min
26. Regulation of intracellular calcium signaling, localized signals and oscillations- Prof. Barbara Ehrlich
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26 min
27. Modeling Ca2+ signals- Dr. David Friel
- Calcium Effectors
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34 min
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41 min
29. Calcium-regulated adenylyl cyclases and cyclic AMP compartmentalization- Prof. Dermot Cooper
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32 min
30. Calcium and transcription-coupling- Dr. Karen Lounsbury
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50 min
31. Cellular calcium (Ca2+) buffers- Prof. Dr. Beat Schwaller
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24 min
32. Extracellular calcium signaling- Dr. Aldebaran M. Hofer
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50 min
33. Ca2+, fertilization and egg activation- Prof. Karl Swann
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24 min
34. Calcium regulation of transcription in plants- Prof. Hillel Fromm
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34 min
35. Mechanisms regulating STIM expression and function in Ca2+ signaling- Dr. Jonathan Soboloff
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46 min
36. Dynamic signal encoding in the S. cerevisiae calcium response- Dr. Chiraj Dalal
- Calcium and Disease
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43 min
37. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease- Prof. Laura del Senno
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28 min
38. Ca2+ alterations in familial Alzheimer's disease (FAD)- Dr. Paola Pizzo
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38 min
39. Pancreatitis and calcium signaling- Prof. Ole Petersen
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47 min
40. Mechanism-based therapies for heart failure and cardiac arrhythmias- Prof. Andrew Marks
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46 min
41. Genetic defects and calcium- Prof. Tullio Pozzan
- Archived Lectures *These may not cover the latest advances in the field
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31 min
42. Calcium, calmodulin and calcineurin- Prof. Stephen Bolsover
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34 min
43. Calcium flickers steer cell migration- Prof. Heping Cheng
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28 min
44. Automated Ca2+ imaging of chemosensory neurones in C.elegans- Dr. Nikos Chronis
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46 min
45. Ca2+ and the regulation of small GTPases- Prof. Peter Cullen
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35 min
46. Genetically encoded Ca2+ indicators: molecular scale measurements in mammals in vivo- Dr. Michael I. Kotlikoff
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35 min
47. Capacitative (store-operated) calcium entry- Dr. Jim Putney
Printable Handouts
Navigable Slide Index
- Introduction
- Complex protein interactions in local domains
- Cellular reactions in Ca2+- ‘nanodomains‘
- Analysis of protein nano-environments
- Experimental approach: mouse & rat brain
- Experimental approach: solubilization
- Experimental approach: affinity purification
- Experimental approach: MS analysis
- Quantification and evaluation (1)
- Quantification and evaluation (2)
- Nano-environments of Cav2 channels
- Details and ‘settings‘ of the proteomic approach
- Nano-environment: the channels‘ core
- Nano-environment: identified protein constituents
- Nano-environment circuitry
- Molecular model of Cav2 nano-environment (1)
- Molecular model of Cav2 nano-environment (2)
- Molecular model of Cav2 nano-environment (3)
- BKCa-Cav2 channels complexes (1)
- BKCa-Cav2 channels complexes (2)
- BKCa-Cav2.1 complexes in X. oocytes
- BKCa-Cav2.1: a prototypic ‘Ca2+ nano-domain‘
- Summary and conclusions
- Acknowledgements
Topics Covered
- Significance and molecular organization of local Ca2+ signalling
- Proteomic analysis of the nano-environment of voltage-gated Ca2+ (Cav) channels
- Structure and operation of the Cav2 channels from mammalian brain
- Operation of Cav-BK channel complexes
- Cav-BK complex as a prototypic Ca2+ nano-domain
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Talk Citation
Fakler, B. (2013, October 7). Protein networks of voltage-gated Ca2+ channels – proteomic & functional analysis of local Ca2+ signalling [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 26, 2021, from https://hstalks.com/bs/2647/.Publication History
Financial Disclosures
- Prof. Bernd Fakler has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Protein networks of voltage-gated Ca2+ channels – proteomic & functional analysis of local Ca2+ signalling
Published on October 7, 2013
34 min
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