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1. Introduction
2. Talk outline
3. Gamma C family cytokines
4. Importance of gamma C cytokines
5. Cytokines
6. Type I and type II cytokines
7. Type I cytokines
8. GH/GHR complex
9. IL-2
10. IL-2 receptors
11. IL-2 - IL2R interaction
12. The high affinity IL-2 receptor
13. Two receptor components in gamma C cytokines
14. The expanded "IL-2 family" of cytokines
15. X-linked severe combined immunodeficiency
16. Basis for T, NK, and B-cell defects in XSCID
17. Why share gamma C? (1)
18. Why share gamma C? (2)
19. Why share gamma C? (3)
20. Cytokine pleiotropy and redundancy
21. Cytokine receptor pleiotropy and redundancy
22. IL-2 activates multiple signaling pathways
23. JAK-STAT pathway
24. Pleiotropic use of JAKs
25. Causes of T-B+NK- and T-B+NK+ SCID
26. What is the basis for signaling specificity?
27. Pleiotropic use of STATs
28. Gamma C family cytokine sources - summary
29. Actions of IL-2
30. Therapy related to IL-2
31. Activities of IL-4
32. Activities of IL-7
33. Activities of IL-9
34. Activities of IL-15
35. Pleiotropic actions of IL-21
36. Activities of IL-21
37. Clinical potential of IL-21
38. Cells with receptor chains for gamma C cytokines
39. Summary
40. Acknowledgements

Topics Covered

• The gamma c family of cytokines
• General features of cytokines
• Cytokine and cytokine receptor pleiotropy and redundancy
• The gamma c family of cytokines and its relationship to X-linked severe combined immunodeficiency
• Features of gamma c family cytokines (IL-2, IL-4, IL-9, IL-9, IL-15, and IL-21)
• Clinical potential of gamma c cytokines

Links

Series:

• Cytokines

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on December 18, 2012

Financial Disclosures

• Dr. Warren J. Leonard has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.