Inflammation: purposes, mechanisms and development
47 min
- View the Talks
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25 min
1. Mononuclear phagocytes - origins, fates and functions- Prof. Steffen Jung
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39 min
2. Transcription factors in macrophage differentiation- Dr. Michael Sieweke
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44 min
3. Fetal macrophages- Prof. Paul Martin
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44 min
4. The alveolar macrophage- Dr. Ronald G. Crystal
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35 min
5. Airway macrophages in health and disease- Prof. Tracy Hussell
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65 min
6. Intestinal macrophages - heterogeneity, origins and functions- Prof. Allan Mowat
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27 min
7. Osteoclasts: what do they do and how do they do it?- Prof. Steven L. Teitelbaum
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51 min
8. The biology of Fc receptors and complement receptors- Prof. Steven Greenberg
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71 min
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38 min
10. Tumour-associated macrophages- Prof. Michele De Palma
- Dr. Mario Squadrito
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42 min
11. The recognition of pathogens by C-type lectins- Prof. Gordon Brown
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34 min
12. Macrophage phagocytosis- Prof. Joel Swanson
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30 min
13. Macrophage CD36 and atherosclerosis- Dr. Maria Febbraio
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31 min
14. Toll-Like receptor signaling and the innate immune response- Dr. Kate Fitzgerald
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43 min
15. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria- Prof. Ricardo Gazzinelli
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34 min
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69 min
17. Triggering receptors expressed on myeloid cells (TREM)- Dr. Daniel W. McVicar
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60 min
18. Influence of eicosanoid lipid mediators on macrophage innate immune functions- Prof. Marc Peters-Golden
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47 min
19. Macrophage paired receptor interactions- Prof. Neil Barclay
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45 min
20. Macrophage heterogeneity in atherosclerosis regression- Prof. Edward Fisher
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35 min
21. Gaucher disease: from lysosomal storage to immunopathology- Prof. Johannes M.F.G. Aerts
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26 min
22. Macrophage in asthma- Prof. Douglas Robinson
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51 min
23. The macrophage mannose receptor- Dr. Luisa Martinez-Pomares
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49 min
24. Immunosuppressive mechanisms in myeloid cells- Prof. Dmitry Gabrilovich
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29 min
25. EGF-TM7 receptors- Dr. Jörg Hamann
- Dr. Hsi-Hsien Lin
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37 min
26. Macrophages in helminth infection- Prof. Judith Allen
Printable Handouts
Navigable Slide Index
- Introduction
- Generation of the F4/80 mAb for macrophages
- F4/80 pan-macrophage marker
- F4/80 antigen revealed it as a 7-TM receptor
- EGF-TM7-R: novel type of heptahelical receptor
- GRAFS classification of GPCRs
- Human adhesion GPCRs
- Evolution
- Expression
- Exp. restricted to eosinophilic granulocytes
- Structure
- Autocatalytic proteolysis of EMR3
- Homo-, hetero-dimerization of adhesion-GPCRs
- Complement regulator CD55 is a ligand of CD97
- EMR2 and CD97 bind chondroitin sulfate B
- CD97 has several cellular ligands
- CD97 antibodies affect granulocyte accumulation
- Granulopoietic activity in CD55 and CD97 KO mice
- CD97 overexpression strengthens cell junctions
- F4/80 required for peripheral tolerance
- EMR2, priming neutrophil migration and activation
- EMR2 signaling
- EGF-TM7 receptors at a glance
- Outstanding questions
- Acknowledgments
Topics Covered
- F4/80 is a marker for mouse macrophages
- The EGF-TM7 receptors EMR1 (F4/80), EMR2, EMR3, EMR4 and CD97 belong to the adhesion class of GPCRs
- Evolution, expression and structure of EGF-TM7 receptors
- EGF-TM7 receptors bind cell- and matrix-associated ligands
- Role of EGF-TM7 receptors in immunity
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Hamann, J. and Lin, H. (2012, May 8). EGF-TM7 receptors [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 26, 2023, from https://hstalks.com/bs/2323/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Jörg Hamann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Dr. Hsi-Hsien Lin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
