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1. Introduction
2. Generation of the F4/80 mAb for macrophages
3. F4/80 pan-macrophage marker
4. F4/80 antigen revealed it as a 7-TM receptor
5. EGF-TM7-R: novel type of heptahelical receptor
6. GRAFS classification of GPCRs
7. Human adhesion GPCRs
8. Evolution
9. Expression
10. Exp. restricted to eosinophilic granulocytes
11. Structure
12. Autocatalytic proteolysis of EMR3
13. Homo-, hetero-dimerization of adhesion-GPCRs
14. Complement regulator CD55 is a ligand of CD97
15. EMR2 and CD97 bind chondroitin sulfate B
16. CD97 has several cellular ligands
17. CD97 antibodies affect granulocyte accumulation
18. Granulopoietic activity in CD55 and CD97 KO mice
19. CD97 overexpression strengthens cell junctions
20. F4/80 required for peripheral tolerance
21. EMR2, priming neutrophil migration and activation
22. EMR2 signaling
23. EGF-TM7 receptors at a glance
24. Outstanding questions
25. Acknowledgments

Topics Covered

• F4/80 is a marker for mouse macrophages
• The EGF-TM7 receptors EMR1 (F4/80), EMR2, EMR3, EMR4 and CD97 belong to the adhesion class of GPCRs
• Evolution, expression and structure of EGF-TM7 receptors
• EGF-TM7 receptors bind cell- and matrix-associated ligands
• Role of EGF-TM7 receptors in immunity

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 8, 2012

Financial Disclosures

• Dr. Jörg Hamann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Dr. Hsi-Hsien Lin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.