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Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Asthma pathophysiology
- Clinical phenotypes of asthma
- Anti-IL5 asthma studies
- Anti-IL13 study
- Anti-TNFalpha in patients with refractory asthma
- Anti-TNF-alpha therapies
- Spectrum of steroid responsiveness
- Costs of severe asthma
- How steroids work in the airways
- Classical mechanism of glucocorticoid action
- Dexamethasone induction of MKP-1
- Molecular actions of glucocorticoids
- Dissociation of corticosteroid effects
- GR immunolocalisation in sputum cells
- Effect of FP and salmeterol on GR translocation
- Combination therapy
- Relative steroid insensitivity
- Skin blanching response to topical budesonide
- Dex fails to suppress selected gene expression
- Effect of dexamethasone on GM-CSF production
- GR beta association with steroid resistance
- MAPKs affect steroid responsiveness
- IL-2/IL-4 affect GR Kd: role of p38 MAPK
- IL-2/IL-4 induces dex-insensitivity in PBMCs
- IL-2/IL-4 modulate GR translocation ability
- Enhanced p38 MAPK activity
- New safer MAPK inhibitors with a topical steroid
- JNK activation is not repressed by prednisolone
- Steroid insensitivity induction by TCR
- Infection and steroid responsiveness
- Increased bacterial LPS expression
- Superantigen-induced GR insensitivity
- RV-induced steroid resistance in asthma
- TH-17 associated cytokines
- IL-17 attenuates steroids effects in mice
- Loss of anti-inflammatory mediators
- IL-10
- Vitamin D enhances IL-10 production
- Vitamin D therapy and IL-10 expression
- Smoking reduces steroid function in asthma
- Smoking and steroid response in asthma
- Altered glutathione homeostasis in children
- Oxidative stress prevents GR translocation
- Oxidative stress induces steroid insensitivity
- Inhibitory effect of dex and HDAC activity
- Cigarette smoke reduces HDAC activity
- HAT and HDAC activity in asthmatic biopsies
- Reduced HDAC and increased HAT activity
- Theophylline enhances dexamethasone function
- Randomisation strategy - smoking asthma
- Smoking asthma - lung function (PEF)
- Summary
- Heterogeneity of 'causes' of CS insensitivity
- Relationship between drivers of steroid resistance
- Conclusion
- Acknowledgements
Topics Covered
- Overview of asthma pathophysiology
- Patterns of severe refractory asthma
- Methods to improve steroid efficacy in severe asthma
- Mechanisms that induce steroid insensitivity; Th2 cytokines, IL-17 and infections
- Pathophysiology of severe treatment refractory asthma
- Novel anti-inflammatory approaches
- Can new combinations of drugs reverse steroid insensitivity in severe asthma?
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Talk Citation
Adcock, I. (2011, December 29). Steroid resistance in asthma: mechanisms and potential therapies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 16, 2024, from https://doi.org/10.69645/EHHY3796.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Ian Adcock has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.