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1. Introduction
2. Overview
3. What constitutes and characterizes asthma?
4. Airway inflammation
5. What constitutes inflammation in asthma?
6. Multiple components of inflammation in asthma
7. Components of inflammation in asthma
8. Key components of inflammation in asthma
9. Mast cells in asthma
10. The role of mast cells in asthma
11. Biology of the airway response to antigen
12. What happens if the mast cell is "disarmed"?
13. Treatment with omalizumab on IgE-bearing cells
14. Omalizumab effect on asthma - reference
15. Omalizumab effect on asthma - study results
16. Omalizumab effect on asthma exacerbations
17. Omalizumab effect on asthma over a year
18. Allergic sensitization and "September epidemics"
19. What is the role of the eosinophil in asthma?
20. Eosinophil
21. Actions of IL-5
22. Removing one of the inflammatory cells (1)
23. The effect on lung function
24. Mepolizumab reduces exacerbations
25. Lymphocyte role in asthma
26. Sub-populations of lymphocytes in asthma
27. IL-4/13 actions
28. IL-13 importance
29. Gene expression microarray
30. Expression of three genes induced by IL-13
31. Expression levels of the Th2 cytokines
32. Th2 high asthma patience response
33. Responsiveness to inhaled steroids
34. Characteristics of Th2-asthma phenotype
35. Anti IL-13 effect
36. Anti IL-13 study results
37. Eosinophil sub populations
38. Regulatory T cells
39. TGF-beta
40. Activating regulatory pathways
41. Th17
42. Th17 effect on asthma
43. IL-17 and asthma
44. Neutrophils and asthma
45. IL-33 pathway
46. IL-33
47. IL-13 enhancing activity
48. Summary

Topics Covered

• Airway inflammation is a complex, interactive, redundant immune response
• Components of inflammation in asthma
• "Traditional" inflammatory cells in airway inflammation
• Mast cells and eosinophils
• Lymphocytes
• Using monoclonal antibodies to gain insight into the clinical significance of inflammation in asthma
• IgE, IL-5, and IL-13
• The diversity of patterns of inflammation in asthma
• Personalized medicine

Links

Series:

• Advances in Asthma

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on February 19, 2012

Financial Disclosures

• Prof. William Busse has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.