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- Advances in the Understanding of Etiology (I)
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30 min
1. Infection and autoimmunity: a two-way relationship- Dr. Ricard Cervera
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35 min
2. Autoimmunity and atherosclerosis- Prof. Johan Frostegard
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47 min
3. Endothelium and autoimmunity- Prof. Pier Luigi Meroni
- Advances in the Understanding of Etiology (II)
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22 min
4. Prolactin has a pathogenic role in systemic lupus erythematosus- Prof. Luis Jara-Quezada
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44 min
5. Sjögren's syndrome: current knowledge and future prospects- Prof. Athanasios G. Tzioufas
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51 min
6. Genetic and environmental triggers of autoimmune thyroid diseases- Prof. Yaron Tomer
- Advances in Pathogenesis and Clinical Manifestation
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38 min
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20 min
8. Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes- Dr. Luís Eduardo Coelho Andrade
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34 min
9. Pathogenic mechanisms of autoantibodies: antibodies to intracellular and membrane-bound antigens- Dr. Luís Eduardo Coelho Andrade
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43 min
10. What causes primary biliary cholangitis?- Dr. M. Eric Gershwin
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30 min
11. Capillaroscopy in autoimmune rheumatic diseases- Prof. Maurizio Cutolo
- Advances in Diagnostic Methodologies (I)
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26 min
12. The past, present & future of ANA testing: history and challenges of ANA- Prof. Marvin J. Fritzler
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33 min
13. The past, present & future of ANA testing: changing bandwidth and future of ANA- Prof. Marvin J. Fritzler
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36 min
14. Diagnostic methods in autoimmunity- Mr. Steven Binder
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24 min
15. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 1- Prof. Chaim Putterman
- Dr. Noa Schwartz
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28 min
16. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 2- Prof. Chaim Putterman
- Dr. Noa Schwartz
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48 min
17. Novel aspects of systemic sclerosis- Prof. Gabriele Valentini
- Advances in Diagnostic Methodologies (II)
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46 min
18. An update on the multiple faces of celiac disease- Prof. Aaron Lerner
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23 min
19. Protective autoantibodies- Prof. Elias Toubi
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32 min
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44 min
21. Rheumatic fever: a model of a post-infectious autoimmune disease- Prof. Jorge Kalil
- Treatments of autoimmune diseases
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38 min
22. Intravenous immunoglobulins: clinical evidence- Prof. Shaye Kivity
- Latest Developments in the Field
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26 min
23. Adjuvants and autoimmunity- Dr. Eitan Israeli
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46 min
24. Antiphospholipid syndrome (APS): from pathogenesis to treatment- Prof. Roger Levy
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24 min
25. Vitamin D and autoimmunity- Dr. Shir Azrielant
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28 min
26. Pregnancy in rheumatic diseases- Prof. Pier Luigi Meroni
- Archived Lectures *These may not cover the latest advances in the field
-
47 min
27. Pathogenic mechanisms of autoantibodies- Prof. Cees Kallenberg
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41 min
28. B lymphocytes on the frontline of autoimmunity- Prof. Pierre Youinou
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42 min
29. Apoptotic cell clearance deficiency- Prof. Martin Herrmann
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34 min
30. Auto-antibodies as predictors of autoimmune disease- Dr. Nicola Bizzaro
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46 min
31. Innate immunity and natural autoantibodies- Prof. Luc Mouthon
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45 min
32. Accelerated atherosclerosis in autoimmune rheumatic disease- Dr. Andrea Doria
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47 min
33. Pregnancy in autoimmune rheumatic diseases- Prof. Angela Tincani
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42 min
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39 min
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24 min
36. Immunologic mechanisms in systemic lupus erythematosus- Prof. Kok-Yong Fong
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23 min
37. Osteoimmunology- Prof. João Eurico Fonseca
- Ms. Joana Caetano-Lopes
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43 min
38. ANCA-associated systemic vasculitides- Prof. Loic Guillevin
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23 min
39. The common origin for diverse autoimmune diseases- Prof. Juan-Manuel Anaya
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76 min
40. Anti-cytokine therapy in rheumatoid arthritis- Prof. Piercarlo Sarzi-Puttini
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40 min
41. Sjogren's syndrome: autoimmune epithelitis- Prof. Haralampos Moutsopoulos
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31 min
42. Vitamin D and autoimmunity- Dr. Howard Amital
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25 min
43. Intravenous immunoglobulins: myth and reality- Prof. Zera Tellier
Printable Handouts
Navigable Slide Index
- Introduction
- Subpopulations of B cells
- The CD5+ marker in B cells
- Two features of CD5+ B cells
- B-1a, B-1b and B-2
- Origine of B1 cells
- Association with the BCR
- Ontogenesis of B-cells
- The issue of the marginal zone B cell
- Two differentiation pathways of plasma cells
- Cell interactions in germinal center
- Lymphoid follicle
- B cells multifaceted activity
- Recombination activating genes
- MRL / lpr model
- Effects of B cells on dendritic cells
- Antigen presenting cells
- Cellular and antibody responses
- Production of cytokines
- Tolerance breakdown
- B-cell tolerance
- Mouse models for anergy
- Modulation of the BCR threshold
- CD19 and CD21
- RAG1+, RAG2+
- Tuning the message
- Lipid rafts
- The kinetics of lipid rafts phenomenon
- B cell activating factor of the TNF family
- Serum level of BAFF in disease
- Epithelial cells produce BAFF
- CD5 gene
- The usage of CD5-E1B is restricted to B cells
- The synthesis of the truncated CD5+ protein
- Conventional/alternative exon 1
- In summary
- Aknowledgements
Topics Covered
- Subpopulations of B cells
- CD5-positive B cells
- Marginal zone B cells
- Follicular B cells
- Pathogenic B cells
- Cytokine-producing B cells
- B cells and tolerance
- BCR co-receptor molecules
- Lipid rafts
- BAFF in autoimmunity
- The CD5 molecule in tolerance
Talk Citation
Youinou, P. (2007, October 1). B lymphocytes on the frontline of autoimmunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 10, 2024, from https://doi.org/10.69645/TCVK2818.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Pierre Youinou has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
