Pathways of apoptosis in muscle 1

Published on October 1, 2007 Updated on December 2, 2018   47 min

Other Talks in the Category: Cancer

In this talk, I will focus on apoptotic pathways that have been shown to be active in skeletal muscle during periods of muscle loss.
Apoptosis in skeletal muscle occurs under various conditions and in pathological and non-pathological perturbations. This include but are not limited to muscle loading, aging, muscle disuse, and denervation. Conditions of extreme muscle loading and bulky apoptotic signaling, perhaps in part, a result of muscle damage or increases in oxidative stress to the muscle. Although resistance exercise has been used to offset muscle loss with aging, sarcopenia or muscle wasting with age is inevitable. Apoptosis has a role in regulating sarcopenic loss of muscle fiber number, controlling atrophy of the existing muscle fibers, and regulating at least in part the degree to which hypertrophy can occur in loaded muscles. Unloading and disuse, whether by prolonged bed rest or experimentally in animals reduces muscle mass and invokes apoptotic signaling. Denervation by loss of the motor nerve to the muscle, whether by directly severing the nerve or by spinal cord injury results in massive muscle loss, and this is accompanied by increased apoptotic signaling in the muscle.
Apoptosis in skeletal muscle is more precisely described as nuclear apoptosis.