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Hello, my name is Demet Arac,
and I'm an assistant professor at
the Department of Biochemistry and Molecular Biology at the University of Chicago.
My lab's primary focus is understanding the mechanisms of
adhesion GPCR action using structural and functional tools.
Today, I will be talking to you about
the structures and functions of adhesion GPCRs and their ligands.
The outline of this talk includes history,
biological function, and the architecture of adhesion GPCRs,
followed by the description of a conserved domain of adhesion GPCRs,
called the GAIN domain;
the working models for adhesion GPCR activation,
the structures of adhesion GPCR extracellular regions, and their ligands;
the similarity of adhesion GPCRs to hormone receptors,
and how adhesion GPCRs may be drugged.
The first adhesion GPCR was described in 1981,
and since then a total of 33 adhesion GPCRs were described in humans,
making adhesion GPCRs the second-largest GPCR family.
These genes are very large and complex genes,
and thus, they were often ignored by most studies.
As a result, adhesion GPCRs remains the
least studied and least understood family of GPCRs.
Initially, adhesion GPCRs were classified under the class B GPCRs.
In 2003, they were classified as a separate GPCR family,
and were named the adhesion GPCRs.