Fuzzy protein theory for disordered proteins

Published on March 29, 2017   40 min

Other Talks in the Series: Protein Folding, Aggregation and Design

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Fuzzy Theory for Disordered Proteins by Monika Fuxreiter, Laboratory of Protein Dynamics, University of Debrecen, Hungary. Today, I'm going to discuss the molecular basis for the intelligent decision making of proteins using the framework of the fuzzy theory.
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All cellular processes are determined by a vast number of interactions between many different kinds of biomolecules, proteins, nucleic acids, and small organic substrates. Molecular organizations and the synergy between a variety of interactions control the response to the environmental signals. Characteristics of the biomolecular assemblies regulate the biological output, and ultimately, the healthy or pathological nature of a biochemical process.
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Protein interactions need to be selective for their partners, which are recognized and also need to be specific to the circumstances where the interactions take place. Here I show interactions which are specific to different tissues. Alternative splicing can rewire the interaction networks in different cell types by alternative inclusion of the binding elements. Protein assemblies must also be specific to the signals which trigger the contacts between the molecules. All interactions must be tightly regulated by the environmental conditions which affect the temporal and spatial characteristics and the functional consequences of the assembly.