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1. Non-P450 oxidative metabolism
2. Enzymes catalysing non-P450 (1)
3. Enzymes catalysing non-P450 (2)
4. Non-P450 oxidative metabolism
5. Molybdenum hydroxylases XO/AO
6. Molybd. hydrox. - properties
7. XO/AO - catalysed reactions
8. XO/AO - substrate specificity
9. Molybd. hydrox. - subst. oxidation
10. XO - in vivo electron transfer
11. AO - in vivo electron transfer
12. XO/AO-generated ROS species
13. XO - substrates for oxidation
14. AO - activation of famciclovir
15. AO - uncharged N-heterocyclic
16. Oxidative metabolism of zaleplon
17. AO - charged N-heterocyclic
18. AO - oxidation of N1-methylnic.
19. AO - aldehyde substrates
20. Human molybd. hydrox. Activity
21. Molybd. hydrox. - induc./inhibit.
22. Raloxifene - potent AO inhibitor
23. AO and XO/XDH genes
24. Molybd. hydrox. - genetic deficien.
25. Alcohol/aldehyde dehydrogenases
26. Alcohol oxidation
27. Alcohol dehydrogenase (ADH) (1)
28. Alcohol dehydrogenase (ADH) (2)
29. Aldehyde oxidation
30. Aldehyde dehydrogenase (ALDH)
31. ALDH - catalytic mechanism
32. ALDH - properties
33. ALDH - endogenous substrates
34. ALDH - polymorphism
35. Monoamine oxidase (MAO)
36. MAO - properties
37. Flavin Monooxygenases (FMO)
38. FMO - catalytic reaction
39. FMO - isozymes
40. FMO - catalytic cycle
41. FMO - substrate specificity
42. FMO - oxidation of 1'/2' amines
43. FMO - oxidation of 3' amines
44. FMO - amine substrates
45. FMO - (S)-nicotine oxidation
46. Sulphur-contain. drugs/xenobiotics
47. FMO - stereoselective S-oxidation
48. FMO - genetic polymorphism
49. FMO - Inhibition/induction
50. Co-oxidation of drugs
51. Prostaglandin synthase PGHS (1)
52. Prostaglandin synthase PGHS (2)
53. Lipoxygenases (LO)
54. Summary

Topics Covered

• Cytosolic, mitochondrial and microsomal enzymes in drug oxidation
• Molybdoflavoproteins
• Aldehyde oxidase
• Xanthine oxidase
• NAD(P)-dependent aldehyde dehydrogenase
• NAD+-dependent alcohol dehydrogenase
• Monoamine oxidase
• Flavin Monooxygenase
• Co-oxidation by prostaglandin synthase and lipoxygenases
• Role in drug activation and inactivation
• Factors affecting activity

Links

Series:

• Drug Metabolizing Enzymes

Categories:

• Cell Biology
• Metabolism & Nutrition
• Pharmaceutical Sciences

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Beedham, C. (2007, October 1). Non-P450 oxidative metabolism: characteristics and drug substrates [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved June 21, 2018, from https://hstalks.com/bs/688/.

Talk Information

• Published on October 1, 2007