Share these talks and lectures with your colleagues
Invite colleaguesWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at support@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support support@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support support@hstalks.com
We hope you have enjoyed this limited-length demo talk
This is a limited length demo talk; you may
login
or review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Alternative oxidative metabolism enzymes
- Lecture summary
- Molybdenum hydroxylases
- Properties of molybdenum hydroxylases
- Reactions catalysed by AO and XO
- Substrate specificity of AO and XO
- Molybdenum hydroxylase catalysed oxidation
- In vivo electron transfer xanthine dehydrogenase
- In vivo electron transfer aldehyde oxidase
- Reactive oxygen species
- Substrates of XO - Oxidation
- Activation of Famciclovir by AO
- Uncharged N-heterocyclic substrates of AO
- Oxidative metabolism of Zaleplon
- Charged N-heterocyclic substrates of AO
- Aldehyde substrates of AO
- Human molybdenum hydroxylase activity
- Induction & inhibition of molybdenum hydroxylases
- AO and XO/XDH genes
- Variability in human liver aldehyde oxidase activity
- SNPs Xanthine Oxidase
- Genetic deficiencies in molybdenum hydroxylases
- ADH and ALDH
- Alcohol Dehydrogenase (ADH) (1)
- Alcohol Dehydrogenase (ADH) (2)
- Aldehyde oxidation
- Aldehyde Dehydrogenase (ALDH)
- Properties of ALDH
- Endogenous ALDH substrates
- ALDH polymorphism
- Amine oxidases
- Monoamine oxidase (MAO)
- Properties of MAO
- Flavin monooxygenases (FMO)
- FMO isozymes
- Catalytic cycle of FMO
- Substrate specificty of FMOs
- FMO oxidation of primary & secondary amines
- FMO oxidation of aliphatic tertiary amines
- Stereoselective oxidation of (S)-nicotine
- Sulphur containing drugs and xenobiotics
- Stereoselective S-oxidation of cimetidine
- FMO5 & Baeyer-Villiger oxidation
- Genetic polymorphism of FMO
- Inhibition and induction of FMO
- Lecture summary
- Thank you
Topics Covered
- Non-P450 cytosolic and mitochondrial enzymes catalysing drug oxidation
- Aldehyde oxidase and xanthine oxidase
- Alcohol dehydrogenase and aldehyde dehydrogenase
- Monoamine oxidase
- Flavin monooxygenase
- Substrate specificities
- Drug and xenobiotic substrates
- Catalytic mechanism and metabolite formation
- Reactive oxygen species
- Factors affecting enzyme activity
- Polymorphism and isozymes
- Relative importance in drug metabolism