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- Cellular Mechanisms of Mitochondrial Biogenesis in Health
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1. Nuclear control of electron transport chain gene expression
- Dr. Glenn C. Rowe
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3. Protein import into mitochondria
- Dr. Trevor Lithgow
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4. Mitochondrial phospholipid synthesis and incorporation
- Prof. Grant Hatch
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5. Mitochondrial DNA replication and transcription
- Prof. Julio Montoya
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6. Mitochondrial production of reactive oxygen species 1
- Prof. Martin Brand
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7. Mitochondrial production of reactive oxygen species 2
- Prof. Martin Brand
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8. Mitophagy - the degradation of dysfunctional organelles
- Dr. Anna Vainshtein
- Mitochondrial Biogenesis in Physiological Conditions
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9. Thyroid hormone and mitochondrial biogenesis
- Dr. Joachim Weitzel
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10. Exercise-induced mitochondrial biogenesis in muscle 1
- Prof. David Hood
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11. Exercise-induced mitochondrial biogenesis in muscle 2
- Prof. David Hood
- Mitochondrial Biogenesis in Aging and Disease
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12. Mitochondrial diseases: an update
- Dr. Ayesha Saleem
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13. Exercise and nutrition in mitochondrial disorders
- Prof. Mark Tarnopolsky
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14. Mitochondrial disorders and neurodegeneration
- Dr. Jan-Willem Taanman
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15. Reprogramming oxidative phosphorylation in cancer
- Prof. José Cuezva
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16. Possible roles of mitochondrial biogenesis in aging
- Dr. Aubrey de Grey
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17. Mitochondria in reproduction and fertility: mitochondria and gametes 1
- Prof. Pascale May Panloup
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18. Mitochondria in reproduction and fertility: mitochondria and embryo 2
- Prof. Pascale May Panloup
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19. Mitochondrial morphology and ultrastructure in skeletal muscle
- Prof. Martin Picard
- Mitochondria, Cell Signaling and Apoptosis
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20. Mitochondrial permeability transition
- Prof. John Lemasters
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21. Pathways of apoptosis in muscle 1
- Prof. Stephen E. Alway
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22. Pathways of apoptosis in muscle 2
- Prof. Stephen E. Alway
- Archived Lectures *These may not cover the latest advances in the field
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25. Reactive oxygen species and myocardial apoptosis
- Dr. Zhi-Qing Zhao
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26. Mitochondrial biogenesis as a result of exercise
- Dr. Darrell Neufer
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27. Mechanisms of mitochondrial fusion and fission
- Dr. Luca Scorrano
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28. Mitochondrial heterogeneity in cells
- Dr. Tony Collins
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29. Mitochondrial diseases: an update
- Prof. Salvatore DiMauro
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30. Calcium signaling and mitochondrial function
- Prof. David Nicholls
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31. Mitochondrial biogenesis during gametogenesis and embryonic development
- Prof. Pascal Reynier
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32. Mitochondrial complex assembly
- Dr. Leo Nijtmans
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33. Evolutionary and developmental variation in muscle mitochondrial content
- Prof. Christopher Moyes
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34. Muscle mitochondrial function and biogenesis with aging
- Dr. Russell Hepple
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35. The mitochondrial pathway in apoptosis
- Prof. Douglas Green
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37. Mitochondrial disorders and neurodegeneration
- Prof. Anthony Schapira
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38. Respiration, reactive oxygen species and uncoupling proteins
- Prof. Martin Brand
Printable Handouts
Navigable Slide Index
- Introduction
- Mitochondrial permeability transition (MPT)
- Mitochondrial swelling after MPT induction
- Calcium induced MPT
- Calcium transition-inducing agents
- Discrepancies of the consensus model
- Alternative protein misfolding model of the MPT
- Low vs. high mastoparane doses effect on MPT
- Heat shock effect on Hsp25 protein expression
- Shift of isoelectric point of RISP at MPT onset
- Phosphatase shifts pI of RISP
- RISP and complex III migration in native gels
- The activity of CsA in immune response and MPT
- Amphiphiles and the MPT
- Mitochondrial swelling in Reye's syndrome
- Salicylate but not Aspirin induces the MPT
- Substances in Reye-related drug toxicities
- Does the MPT really occur in living cells?
- Ischemia\reperfusion and MPT in living cells
- Inner membrane permeabilization after reperfusion
- Cell killing in pH-dependent reperfusion injury
- TNF-alpha-induced depolarization and permeability
- CsA blocks TNF-alpha
- Apoptotic signaling after TNF-alpha
- Events after ischemia/reperfusion in rat liver
- Oxidative stress-induced MPT
- Necrapoptosis
- Cell death signals converging at the mitochondria
- Role of MPT in cells that are not dying
- Mitochondrial depolarization inhibition by CsA
- Mitochondrial autophagy (mitophagy)
- Mitophagy in GFP-LC3 mouse hepatocytes
- Degradation of mtDNA by mitophagy
- Mitophagy: summary
- MPT - summary
- References (1)
- References (2)
- References (3)
- References (4)
- References (5)
- References (6)
Topics Covered
- Factors regulating opening of permeability transition pores
- Models of permeability transition pore composition
- Discrepancies of consensus model
- Protein misfolding and the MPT
- Rieske iron sulfur protein
- Reye's syndrome
- Ischemia/reperfusion and oxidative stress
- Apoptosis
- Mitochondrial autophagy (mitophagy)
- Necrapoptosis
Talk Citation
Lemasters, J. (2007, October 1). Mitochondrial permeability transition [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 27, 2024, from https://hstalks.com/bs/183/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. John Lemasters has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.