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Printable Handouts
Navigable Slide Index
- Introduction
- Talk overview
- A few introductory notions
- Reminder and graphic convention
- Methylated DNA in 3D
- The number of methylated CpGs per genome
- The distribution of methylated CpGs in cells
- DNA methylation and cancer
- The identification of methyl-binding proteins (MBPs)
- Why look for MBPs in the first place?
- Biochemical identification of MBPs
- Finding other MBPs by homology searches
- Methyl binding proteins: Gel-retardation assay
- Methyl binding proteins: Nuclear localization (1)
- Methyl binding proteins: Nuclear localization (2)
- Methyl binding proteins: Chromatin-IP
- Human methyl-binding proteins list
- What do the methyl-binding proteins do?
- MBPs cause heterochromatinization
- MeCP2, Rett syndrome, and neuronal transcription
- Search for MeCP2 target genes in the mouse brain
- MBD4, cancer, and mutagenesis
- Spontaneous base deamination
- UHRF1 is necessary for embryonic viability
- UHRF1 and the maintenance of DNA methylation
- Kaiso: a bifunctional transcription factor
- Kaiso in colon cancer
- Unresolved questions
- Why are most MBPs non-essential?
- Proteomics yield many new MBP candidates
- New MBPs might be identified by genetic screens
- The role of MBPs in active DNA demethylation?
- Summary
- Identification of methyl-binding proteins
- Three families of methyl-binding proteins
- General model
- Acknowledgements
- Reading suggestions
- References
Topics Covered
- Introductory notions: distribution, abundance, and consequences of DNA methylation
- The methyl-binding proteins: who they are, how they were found
- What do the methyl-binding proteins do? Four examples
- Unresolved questions and future perspectives
- References
Talk Citation
Defossez, P. (2011, March 3). Proteins that bind methylated DNA [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 9, 2024, from https://doi.org/10.69645/PIBB9763.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Pierre-Antoine Defossez has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.