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Printable Handouts
Navigable Slide Index
- Introduction
- Legionella pneumophila
- The Legionella lifecycle
- The dot and icm genes
- dot/Icm define type 4 secretory system
- Dot/Icm and intracellular replication
- Endocytic membrane transport
- Dot/Icm effect on endocytic maturation
- Understanding the function of Dot/Icm
- Dot/Icm and transport of Legionella vacuole
- Legionella subverts vesicular transport
- Legionella replication requires vesicular transport
- ARF function is required for ER remodeling
- ER-derived vesicles and Legionella vacuole
- Host GTPases are used for replication
- The Dot/Icm system modulates Arf
- The Dot/Icm system modulates Rab1
- Control of Arf and Rab GTPases
- Identifying Legionella effector proteins
- Identification of ralF
- RalF is translocated to the bacterial cell
- Dot/Icm delivers RalF to the host cell
- RalF defines a new bacterial member of Sec7
- Activation of Arf by Legionella
- How does Legionella modulate Rab1 function?
- Identification of DrrA
- DrrA functions as a GEF factor
- Other Legionella factors that target Rab1
- DrrA is sufficient for Rab1 recruitment
- DrrA is able to dissociate GDI from Rab1
- DrrA has GDI displacement activity
- DrrA has 2 functions
- LepB interacts specifically with Rab1-GTP (1)
- LepB interacts specifically with Rab1-GTP (2)
- LepB is a Rab1 GAP
- Control of Rab1 membrane cycling
- Legionella: the greatest cell biologist on earth
Topics Covered
- The legionella life cycle
- Identification of the dot and icm genes
- The dot and icm genes define a new type IV secretion system
- Intracellular replication
- Endocytic membrane transport
- Transport of the Legionella-containing vacuole
- Legionella replication
- The dot/icm system modulates Arf and Rab1
- Can we identify Legionella proteins that modulate Arf and Rab1 function?
- Activation of Arf by Legionella
- Can Legionella modulate the function of other host GTPases?
- Identification of DrrA
- LepB
- Legionella: The greatest cell biologist on Earth
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Talk Citation
Roy, C. (2009, October 29). Legionella pneumophila: an intracellular pathogen of phagocytes [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 6, 2024, from https://doi.org/10.69645/VIUB6329.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Craig Roy has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.