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Printable Handouts
Navigable Slide Index
- Introduction
- Circulation and homeostasis of NK cells
- NK cells in secondary lymphoid organs
- Subsets of human peripheral blood NK cells
- NK cells content in secondary lymphoid organs
- FcR and activation markers
- Inhibitory NK receptors
- Activating NK receptors
- Homing markers expressed on NK cells
- Up-regulation of inhibitory & activating receptors
- Activation up-regulates perforin expression
- Part one: summary
- NK cells differentiation
- NK cell activation in secondary lymphoid organs
- NK cell localization in secondary lymphoid organs
- Co localization of NK cells and DCs
- Pathway of transmission of information by DCs
- IFN-gamma production by NK cells
- IFN secretion and proliferation by CD56brightCD16-
- Pathogen pattern that lead to DC maturation
- dsRNA matured DCs - potent NK cell activators
- IL-12 - the dominant cytokine for NK cell activation
- IL-12 is crucial for IFN-gamma secretion
- IL-12 and type I IFN contribute to NK cytotoxicity
- Part two: summary
- Two potential sites of DC/NK interaction
- What is required for full functional capacity of NK?
- The immunological synapse
- NK/DC synapse formation
- Types of immunological synapses
- Formation of productive NK/DC synapses
- NK/DC do not form a classical activating synapse
- Inhibitory NK cell receptors in the synapse
- MHC class I up-regulation protects mature DCs
- IL-15R polarizes to the DC/NK cell synapse
- Activating and inhibitory signals in the synapse
- Synapse disruption compromises NK cell survival
- Blocking of IL-15R compromises NK cell survival
- Part three: summary
- Functional relevance of NK cell activation
- NK cells assist Th1 polarization in lymph nodes
- Function of NK cells in graft vs. host disease
- NK cells and the response to Epstein Barr virus
- NK cells restrict B cell transformation by EBV
- Tonsilar NK cells restrict EBV transformation
- IFN-gamma production by subsets of NK cells
- IFN-gamma restricts B cell transformation by EBV
- Blocking of IFN-gamma inhibits restriction
- Part four: summary
- Non cytotoxic functions of NK cells
- Cross talk of innate lymphocytes
- Acknowledgments
Topics Covered
- Circulation and homeostasis of NK cells
- NK cells in secondary lymphoid organs
- Subsets of human peripheral blood NK cells
- FcR and activation markers
- Inhibitory/ Activating NK receptors
- Homing markers expressed on NK cells
- NK cells differentiation
- Co localization of NK cells and DCs
- Pathway of transmission of information by DCs
- IFN-gamma production by NK cells
- Pathogen pattern that lead to DC maturation
- IL-12- the dominant cytokine for NK cell activation
- The immunological synapse
- MHC class I up-regulation protects mature DCs
- Activating and inhibitory signals in the synapse
- Functional relevance of NK cell activation
- Function of NK cells in graft vs. host disease
- NK cells and the response to Epstein Barr virus
- IFN-gamma production by subsets of NK cells
- Non cytotoxic functions of NK cells
- Cross talk of innate lymphocytes
Links
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Talk Citation
Münz, C. (2010, January 28). NK cell subsets and interactions with dendritic cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 6, 2024, from https://doi.org/10.69645/FEMQ6230.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Christian Münz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.