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1. Introduction
2. Circulation and homeostasis of NK cells
3. NK cells in secondary lymphoid organs
4. Subsets of human peripheral blood NK cells
5. NK cells content in secondary lymphoid organs
6. FcR and activation markers
7. Inhibitory NK receptors
8. Activating NK receptors
9. Homing markers expressed on NK cells
10. Up-regulation of inhibitory & activating receptors
11. Activation up-regulates perforin expression
12. Part one: summary
13. NK cells differentiation
14. NK cell activation in secondary lymphoid organs
15. NK cell localization in secondary lymphoid organs
16. Co localization of NK cells and DCs
17. Pathway of transmission of information by DCs
18. IFN-gamma production by NK cells
19. IFN secretion and proliferation by CD56brightCD16-
20. Pathogen pattern that lead to DC maturation
21. dsRNA matured DCs - potent NK cell activators
22. IL-12 - the dominant cytokine for NK cell activation
23. IL-12 is crucial for IFN-gamma secretion
24. IL-12 and type I IFN contribute to NK cytotoxicity
25. Part two: summary
26. Two potential sites of DC/NK interaction
27. What is required for full functional capacity of NK?
28. The immunological synapse
29. NK/DC synapse formation
30. Types of immunological synapses
31. Formation of productive NK/DC synapses
32. NK/DC do not form a classical activating synapse
33. Inhibitory NK cell receptors in the synapse
34. MHC class I up-regulation protects mature DCs
35. IL-15R polarizes to the DC/NK cell synapse
36. Activating and inhibitory signals in the synapse
37. Synapse disruption compromises NK cell survival
38. Blocking of IL-15R compromises NK cell survival
39. Part three: summary
40. Functional relevance of NK cell activation
41. NK cells assist Th1 polarization in lymph nodes
42. Function of NK cells in graft vs. host disease
43. NK cells and the response to Epstein Barr virus
44. NK cells restrict B cell transformation by EBV
45. Tonsilar NK cells restrict EBV transformation
46. IFN-gamma production by subsets of NK cells
47. IFN-gamma restricts B cell transformation by EBV
48. Blocking of IFN-gamma inhibits restriction
49. Part four: summary
50. Non cytotoxic functions of NK cells
51. Cross talk of innate lymphocytes
52. Acknowledgments

Topics Covered

• Circulation and homeostasis of NK cells
• NK cells in secondary lymphoid organs
• Subsets of human peripheral blood NK cells
• FcR and activation markers
• Inhibitory/ Activating NK receptors
• Homing markers expressed on NK cells
• NK cells differentiation
• Co localization of NK cells and DCs
• Pathway of transmission of information by DCs
• IFN-gamma production by NK cells
• Pathogen pattern that lead to DC maturation
• IL-12- the dominant cytokine for NK cell activation
• The immunological synapse
• MHC class I up-regulation protects mature DCs
• Activating and inhibitory signals in the synapse
• Functional relevance of NK cell activation
• Function of NK cells in graft vs. host disease
• NK cells and the response to Epstein Barr virus
• IFN-gamma production by subsets of NK cells
• Non cytotoxic functions of NK cells
• Cross talk of innate lymphocytes

Links

Series:

• Natural Killer Cell Biology

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Münz, C. (2010, January 28). NK cell subsets and interactions with dendritic cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/1457/.
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Publication History

• Published on January 28, 2010

Financial Disclosures

• Prof. Christian Münz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.