• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Lecture acknowledgements
3. Lecture outline
4. Section 1 outline
5. Global review: viral life cycle
6. Viral transmission
7. Global review: acute infection
8. Global review: acute infection (2)
9. Mechanism of viral entry
10. Systemic spread of the virus post entry
11. CD4+ depletion in the gut
12. How does GALT depletion affect disease outcome
13. Why does the viral load drop?
14. The host immune response
15. Viral "set point" as a predictor of disease
16. Course of disease
17. Innate and adaptive immune responses cross talk
18. Monocytes and macrophages compartments
19. Monocytes and macrophages: virus reservoirs
20. Macrophages and HIV-1 infection
21. HIV-1 and monocyte apoptosis
22. Human DC subsets
23. Model of DC migration and maturation
24. MHC I antigen presentation
25. Antigen presentation on MHC class I and II
26. Proposed pathways of human DC development
27. Characteristics of human DC
28. DC role during HIV-1 infection
29. Dendritic cell subsets
30. DC decrease upon HIV infection
31. Human DC: C-type lectins
32. Types of C-type lectins expressed on DC
33. Pathogens that bind DC-SIGN
34. Natural killer (NK) cells
35. Direct cytotoxicity through CD8+ T cells
36. Natural killer cell recognition of target cells (1)
37. Natural killer cell recognition of target cells (2)
38. MHC class I locus and NK cells regulation
39. The role of NK cell throughout the disease
40. Role of HLA and KIR alleles in progression to AIDS
41. NK cell and HIV-1 infection
42. To kill or not to kill?
43. Measuring the recovery of patients
44. ART & innate reconstitution
45. RO1 AI51225 - prospective study
46. Recovery of PDC function with HIV-1 suppression
47. Reconstitution of PDC and NK cytotoxicity
48. Model of immune reconstitution time line
49. Section 1 conclusions
50. Section 2 outline
51. Recent paradigm shift: viral load and CD4 loss
52. Immune activation and disease progression
53. Natural SIV host
54. Natural host vs. the HIV model
55. TLR7 and TLR9 signaling and immune activation
56. HIV-1 Nef and immune activation
57. LPS levels are increased in chronic HIV infection
58. Human Toll-like Receptors (TLRs)
59. HIV RNAs can activate T cells via TLR 7, 8
60. TLR activation and CD4 T cells apoptosis
61. TLR induce human T cell activation and death
62. Immune activation hypothesis
63. Disease model
64. Summary model
65. Major hypothesis
66. Thank you

Topics Covered

• Viral life cycle
• Acute infections
• Immune response
• Timeline to effectors
• Stages of immunopathogenesis
• Macrophages and HIV-1 infection
• Monocyte apoptosis
• Human DC subsets
• Model of DC migration and maturation
• MHC I antigen presentation
• Proposed pathways of human DC development
• C-type lectins
• Nature killer cells
• Natural killer cell recognition of target cells
• Role of HLA and KIR alleles in rate of progression to AIDS
• Measuring recovery following immune reconstitution and HIV-1 therapy
• ART and innate reconstitution
• Model of immune reconstitution timeline
• Does the innate immune activation response determine HIV-1 disease?
• Disease models: it's the activation

Links

Series:

• Innate Immunity

Categories:

• Clinical Practice
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on May 31, 2009

Financial Disclosures

• Prof. Luis Montaner has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.