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1. Introduction
2. Lecture acknowledgements
3. Lecture outline
4. Section 1 outline
5. Global review: viral life cycle
6. Viral transmission
7. Global review: acute infection
8. Global review: acute infection (2)
9. Mechanism of viral entry
10. Systemic spread of the virus post entry
11. CD4+ depletion in the gut
12. How does GALT depletion affect disease outcome
13. Why does the viral load drop?
14. The host immune response
15. Viral "set point" as a predictor of disease
16. Course of disease
17. Innate and adaptive immune responses cross talk
18. Monocytes and macrophages compartments
19. Monocytes and macrophages: virus reservoirs
20. Macrophages and HIV-1 infection
21. HIV-1 and monocyte apoptosis
22. Human DC subsets
23. Model of DC migration and maturation
24. MHC I antigen presentation
25. Antigen presentation on MHC class I and II
26. Proposed pathways of human DC development
27. Characteristics of human DC
28. DC role during HIV-1 infection
29. Dendritic cell subsets
30. DC decrease upon HIV infection
31. Human DC: C-type lectins
32. Types of C-type lectins expressed on DC
33. Pathogens that bind DC-SIGN
34. Natural killer (NK) cells
35. Direct cytotoxicity through CD8+ T cells
36. Natural killer cell recognition of target cells (1)
37. Natural killer cell recognition of target cells (2)
38. MHC class I locus and NK cells regulation
39. The role of NK cell throughout the disease
40. Role of HLA and KIR alleles in progression to AIDS
41. NK cell and HIV-1 infection
42. To kill or not to kill?
43. Measuring the recovery of patients
44. ART & innate reconstitution
45. RO1 AI51225 - prospective study
46. Recovery of PDC function with HIV-1 suppression
47. Reconstitution of PDC and NK cytotoxicity
48. Model of immune reconstitution time line
49. Section 1 conclusions
50. Section 2 outline
51. Recent paradigm shift: viral load and CD4 loss
52. Immune activation and disease progression
53. Natural SIV host
54. Natural host vs. the HIV model
55. TLR7 and TLR9 signaling and immune activation
56. HIV-1 Nef and immune activation
57. LPS levels are increased in chronic HIV infection
58. Human Toll-like Receptors (TLRs)
59. HIV RNAs can activate T cells via TLR 7, 8
60. TLR activation and CD4 T cells apoptosis
61. TLR induce human T cell activation and death
62. Immune activation hypothesis
63. Disease model
64. Summary model
65. Major hypothesis
66. Thank you

Topics Covered

• Viral life cycle
• Acute infections
• Immune response
• Timeline to effectors
• Stages of immunopathogenesis
• Macrophages and HIV-1 infection
• Monocyte apoptosis
• Human DC subsets
• Model of DC migration and maturation
• MHC I antigen presentation
• Proposed pathways of human DC development
• C-type lectins
• Nature killer cells
• Natural killer cell recognition of target cells
• Role of HLA and KIR alleles in rate of progression to AIDS
• Measuring recovery following immune reconstitution and HIV-1 therapy
• ART and innate reconstitution
• Model of immune reconstitution timeline
• Does the innate immune activation response determine HIV-1 disease?
• Disease models: it's the activation

Links

Series:

• Innate Immunity

Categories:

• Clinical Practice
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on May 31, 2009

Financial Disclosures

• Prof. Luis Montaner has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.