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- Models of Investigation
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41 min
1. Antifungal innate immunity in C. elegans- Dr. Jonathan Ewbank
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44 min
2. The anti-microbial defense of Drosophila: a paradigm for innate immunity- Prof. Jules Hoffmann
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38 min
3. Phagocytosis in the fruit fly, Drosophila melanogaster- Dr. Lynda Stuart
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62 min
4. Innate immune sensing and response- Prof. Bruce Beutler
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61 min
5. Macrophages and systems biology- Prof. David Hume
- Cell Types and Recruitment
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71 min
6. Leukocyte recruitment in vivo- Prof. Paul Kubes
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51 min
-
42 min
8. Eosinophils- Prof. Tim Williams
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63 min
9. Dendritic cells: linking innate to different forms of adaptive immunity- Prof. Ralph Steinman
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25 min
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61 min
11. Innate-like lymphocytes 1- Prof. Adrian Hayday
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41 min
12. Innate-like lymphocytes 2- Prof. Adrian Hayday
- Recognition and Signaling
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50 min
13. Colony stimulating factor-1 regulation of macrophages in development and disease- Prof. E. Richard Stanley
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42 min
14. Fc receptors: linking innate and acquired immunity- Prof. Ken G C Smith
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39 min
15. Phagocytosis- Prof. Joel Swanson
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44 min
16. Clearance of apoptotic cells and the control of inflammation- Prof. Sir John Savill
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38 min
17. Signaling by innate immune receptors- Prof. Michael Karin
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41 min
18. Nuclear receptors at the crossroads of inflammation and atherosclerosis- Prof. Christopher Glass
- Modulation of Effector Responses
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22 min
19. Humoral innate immunity and the acute phase response 1- Prof. Alberto Mantovani
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42 min
20. Humoral innate immunity and the acute phase response 2- Prof. Alberto Mantovani
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54 min
21. Cytokines regulating the innate response- Prof. Anne O’Garra
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39 min
22. Arginase and nitric oxide- Dr. Peter Murray
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38 min
23. Novel lipid mediators in resolution of inflammation- Prof. Charles Serhan
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69 min
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42 min
25. Cationic peptides in innate immunity- Dr. Dawn Bowdish
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27 min
26. Iron metabolism and innate immunity- Prof. Tomas Ganz
- Pathogen-Host Interactions
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46 min
27. Innate recognition of viruses- Prof. Caetano Reis e Sousa
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50 min
28. Type I interferons in innate immunity to viral infections- Prof. Christine Biron
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56 min
29. HIV-1 and immunopathogenesis: innate immunity- Prof. Luis Montaner
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53 min
30. Understanding and combating tuberculosis- Prof. David Russell
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34 min
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51 min
32. Innate immunity and malaria- Prof. Douglas Golenbock
- Health and Disease
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39 min
33. Innate immunity in children- Prof. David Speert
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59 min
34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis- Prof. Sir Ravinder Maini
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33 min
35. NOD-like receptors in innate immunity and inflammatory disease- Prof. Gabriel Nunez
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38 min
36. Paneth cells in innate immunity and inflammatory bowel disease- Prof. Satish Keshav
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36 min
37. Innate immunity in the brain in health and disease- Prof. V. Hugh Perry
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54 min
38. The fate of monocytes in atherosclerosis- Prof. Gwendolyn Randolph
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49 min
39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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73 min
40. Monocyte/macrophages in innate immunity- Prof. Emeritus Siamon Gordon
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32 min
41. Innate immunity in C. elegans- Dr. Jonathan Ewbank
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51 min
-
39 min
43. NLR genes: infection, inflammation and vaccines- Prof. Jenny Ting
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63 min
44. Manipulation of innate immune response: lessons from shigella- Prof. Philippe Sansonetti
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35 min
45. Innate immunity of the lung and adaptation to air breathing at birth- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- Catabolism of arginine: substrate supply
- Catabolism of arginine: the Krebs urea cycle
- Hepatocytes vs. macrophages
- Regulation of iNOS transcription
- Importance of iNOS in mycobacterial disease
- Structure of arginases
- Evidence for Arg1 regulation by Stat6 pathway
- The type I and II IL-4 and IL-13 receptors
- Mechanism of Arg1 regulation by Stat6 pathway
- Regulation of Arg1 by the Stat3 pathway
- Catabolism of arginine: Arg1 vs. iNOS
- The substrate depletion concept
- Norvaline
- Catabolism of arginine, separation of powers
- Arginases, NO and pathogenesis (1)
- Arginases, NO and pathogenesis (2)
- Arginase and in vivo regulation of NO
- Arginase and in vivo regulation of NO (2)
- Schistosome infection and Arg1(1)
- Schistosome infection and Arg1(2)
- Schistosome infection and AAMs
- Severe periportal fibrosis, genetic components (1)
- Severe periportal fibrosis, genetic components (2)
- Macrophage Arg1 is essential for T cell response
- What about macrophage Arg1 in asthma?
- Arginase inhibitors
- Arginase & NO: unresolved questions
- Thank you
Topics Covered
- Catabolism of arginine to downstream substrates
- Catabolism of arginine in macrophages
- Nitric oxide production
- Control of iNOS at the transcriptional level
- Role of nitric oxide in immunity to intracellular pathogens with a focus on mycobacterial disease
- Structure of arginases
- Transcriptional control of arginase 1 in the liver vs. macrophages
- Arginases can suppress nitric oxide production by substrate depletion
- Pathogens use many mechanisms to regulate nitric oxide
- Arginases and alternatively-activated macrophages (AAMs)
- Schistosome infection as an example of AAM function
- AAMs and arginases
- Arginase inhibition by small molecules
- Outstanding questions
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Murray, P. (2011, August 31). Arginase and nitric oxide [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/ZPMW3102.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Peter Murray has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
