• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Pattern recognition/sensing molecules
3. Identification of the NBD-LRR (NLR) family
4. NLR protein family
5. Members of the NLR gene family
6. Diseases associated with NLR polymorphisms
7. Function of NLR proteins (1)
8. Study I: The multiple functions of NLRP3
9. NLRP3 in IL-1 beta processing and inflammasome
10. The NLR-based inflammasomes (1)
11. Rare gain-of-function mutants of NLRP3 in CAPS
12. Over-expression of NLRP3 leads to cell death
13. Variant NLRP3-induced death is necrotic
14. A model of pathogen-induced necrosis
15. Reduced Shigella-induced cell death in NLRP3-/-
16. Summary: NLRP3 and necrosis
17. The NLR-based inflammasomes (2)
18. ASC and NLRP3 in alum-induced response (1)
19. ASC and NLRP3 in alum-induced response (2)
20. NLRP3 in alum-induced IgE and IgG1 response
21. NLRP3 and IL-1 beta inducing activity of adjuvants
22. New functions of NLRP3
23. Recombinant NLRP3 binds ATPgammaS
24. Recombinant NLRP3 preferentially binds ATP/ADP
25. WA mutation extinguishes ATP-binding activity
26. Assembly with ASC depends on ATP-binding
27. Inflammasome function depends on ATP-binding
28. Study II: NLRX1 and type I IFN
29. NLRX1 is predicted to localize to the mitochondria
30. NLRX1 is found in the mitochondria
31. Signaling pathway for detection of viral RNA
32. NLRX1 localized in mitochondrial outer membrane
33. NLRX1 interacts with MAVS/IPS/VISA/Cardif
34. NLRX1 inhibits MAVS, RIG-I, and MDA-5 signaling
35. NLRX1 siRNA upregulates MAVS-induced IFN-1
36. NLRX1 inhibits RIG-I/MAVS interaction
37. Summary: NLRX1
38. The indirect recognition of PAM by NLR
39. Function of NLR proteins (2)
40. Acknowledgments

Topics Covered

• Pattern recognition/sensing molecules
• Identification of the NBD-LRR (NLR) family
• Autoimmune and Infectious Diseases associated with NLR polymorphisms/mutations
• Functions of NLR proteins
• The multiple functions of NLRP3
• The NLR-based inflammasomes
• Shigella flexneri
• NLRP3 and necrosis
• New functions of NLRP3
• NLRX1
• The indirect recognition of PAM by NLR

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on July 6, 2009
• Archived on February 25, 2021

Financial Disclosures

• Prof. Jenny Ting has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.