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1. Introduction
2. Pattern recognition/sensing molecules
3. Identification of the NBD-LRR (NLR) family
4. NLR protein family
5. Members of the NLR gene family
6. Diseases associated with NLR polymorphisms
7. Function of NLR proteins (1)
8. Study I: The multiple functions of NLRP3
9. NLRP3 in IL-1 beta processing and inflammasome
10. The NLR-based inflammasomes (1)
11. Rare gain-of-function mutants of NLRP3 in CAPS
12. Over-expression of NLRP3 leads to cell death
13. Variant NLRP3-induced death is necrotic
14. A model of pathogen-induced necrosis
15. Reduced Shigella-induced cell death in NLRP3-/-
16. Summary: NLRP3 and necrosis
17. The NLR-based inflammasomes (2)
18. ASC and NLRP3 in alum-induced response (1)
19. ASC and NLRP3 in alum-induced response (2)
20. NLRP3 in alum-induced IgE and IgG1 response
21. NLRP3 and IL-1 beta inducing activity of adjuvants
22. New functions of NLRP3
23. Recombinant NLRP3 binds ATPgammaS
24. Recombinant NLRP3 preferentially binds ATP/ADP
25. WA mutation extinguishes ATP-binding activity
26. Assembly with ASC depends on ATP-binding
27. Inflammasome function depends on ATP-binding
28. Study II: NLRX1 and type I IFN
29. NLRX1 is predicted to localize to the mitochondria
30. NLRX1 is found in the mitochondria
31. Signaling pathway for detection of viral RNA
32. NLRX1 localized in mitochondrial outer membrane
33. NLRX1 interacts with MAVS/IPS/VISA/Cardif
34. NLRX1 inhibits MAVS, RIG-I, and MDA-5 signaling
35. NLRX1 siRNA upregulates MAVS-induced IFN-1
36. NLRX1 inhibits RIG-I/MAVS interaction
37. Summary: NLRX1
38. The indirect recognition of PAM by NLR
39. Function of NLR proteins (2)
40. Acknowledgments

Topics Covered

• Pattern recognition/sensing molecules
• Identification of the NBD-LRR (NLR) family
• Autoimmune and Infectious Diseases associated with NLR polymorphisms/mutations
• Functions of NLR proteins
• The multiple functions of NLRP3
• The NLR-based inflammasomes
• Shigella flexneri
• NLRP3 and necrosis
• New functions of NLRP3
• NLRX1
• The indirect recognition of PAM by NLR

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on July 6, 2009
• Archived on February 25, 2021

Financial Disclosures

• Prof. Jenny Ting has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.