Trauma-informed care (TIC)
61 min
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- Models of Investigation
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41 min
1. Antifungal innate immunity in C. elegans- Dr. Jonathan Ewbank
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44 min
2. The anti-microbial defense of Drosophila: a paradigm for innate immunity- Prof. Jules Hoffmann
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38 min
3. Phagocytosis in the fruit fly, Drosophila melanogaster- Dr. Lynda Stuart
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62 min
4. Innate immune sensing and response- Prof. Bruce Beutler
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61 min
5. Macrophages and systems biology- Prof. David Hume
- Cell Types and Recruitment
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71 min
6. Leukocyte recruitment in vivo- Prof. Paul Kubes
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51 min
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42 min
8. Eosinophils- Prof. Tim Williams
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63 min
9. Dendritic cells: linking innate to different forms of adaptive immunity- Prof. Ralph Steinman
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25 min
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61 min
11. Innate-like lymphocytes 1- Prof. Adrian Hayday
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41 min
12. Innate-like lymphocytes 2- Prof. Adrian Hayday
- Recognition and Signaling
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50 min
13. Colony stimulating factor-1 regulation of macrophages in development and disease- Prof. E. Richard Stanley
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42 min
14. Fc receptors: linking innate and acquired immunity- Prof. Ken G C Smith
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39 min
15. Phagocytosis- Prof. Joel Swanson
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44 min
16. Clearance of apoptotic cells and the control of inflammation- Prof. Sir John Savill
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38 min
17. Signaling by innate immune receptors- Prof. Michael Karin
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41 min
18. Nuclear receptors at the crossroads of inflammation and atherosclerosis- Prof. Christopher Glass
- Modulation of Effector Responses
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22 min
19. Humoral innate immunity and the acute phase response 1- Prof. Alberto Mantovani
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42 min
20. Humoral innate immunity and the acute phase response 2- Prof. Alberto Mantovani
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54 min
21. Cytokines regulating the innate response- Prof. Anne O’Garra
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39 min
22. Arginase and nitric oxide- Dr. Peter Murray
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38 min
23. Novel lipid mediators in resolution of inflammation- Prof. Charles Serhan
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69 min
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42 min
25. Cationic peptides in innate immunity- Dr. Dawn Bowdish
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27 min
26. Iron metabolism and innate immunity- Prof. Tomas Ganz
- Pathogen-Host Interactions
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46 min
27. Innate recognition of viruses- Prof. Caetano Reis e Sousa
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50 min
28. Type I interferons in innate immunity to viral infections- Prof. Christine Biron
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56 min
29. HIV-1 and immunopathogenesis: innate immunity- Prof. Luis Montaner
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53 min
30. Understanding and combating tuberculosis- Prof. David Russell
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34 min
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51 min
32. Innate immunity and malaria- Prof. Douglas Golenbock
- Health and Disease
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39 min
33. Innate immunity in children- Prof. David Speert
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59 min
34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis- Prof. Sir Ravinder Maini
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33 min
35. NOD-like receptors in innate immunity and inflammatory disease- Prof. Gabriel Nunez
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38 min
36. Paneth cells in innate immunity and inflammatory bowel disease- Prof. Satish Keshav
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36 min
37. Innate immunity in the brain in health and disease- Prof. V. Hugh Perry
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54 min
38. The fate of monocytes in atherosclerosis- Prof. Gwendolyn Randolph
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49 min
39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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73 min
40. Monocyte/macrophages in innate immunity- Prof. Emeritus Siamon Gordon
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32 min
41. Innate immunity in C. elegans- Dr. Jonathan Ewbank
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51 min
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39 min
43. NLR genes: infection, inflammation and vaccines- Prof. Jenny Ting
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63 min
44. Manipulation of innate immune response: lessons from shigella- Prof. Philippe Sansonetti
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35 min
45. Innate immunity of the lung and adaptation to air breathing at birth- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- High and low affinity Fc receptors
- Fc receptor family
- FcgammaRIIb: the inhibitory FcR
- FcgammaRIIb on macrophages
- FcgammaRIIb on B-cells
- Crosslinking of FcgammaRII kill plasma cells
- FcgammaRII acting as immune "brake"
- Effects on infection - Strep. pneumoniae
- Strept. pneumoniae in FcgammaRIIb-/- mice
- Balancing bacterial clearance and septic shock
- Over-expression, autoimmunity and infection
- Effects of increasing FcgammaRIIb expression
- FcgammaRIIb transgenic B cells
- FcgammaRIIb transgenic macrophages
- T dependent and independent responses
- FcgammaRIIb and collagen-induced arthritis
- Overexpression of FcgammaRIIb prevents SLE
- FcgammaRIIb expression on macrophages
- Polymorphic variation in FcgammaRIIb
- Systemic lupus erythematosus (1)
- Systemic lupus erythematosus (2)
- 10 genomic regions predispose to SLE
- Clustering of susceptibility loci for autoimmunity
- Fcgamma receptors in mouse and man
- Potential SLE susceptibility genes in Sle1 interval
- FcgammaRII promoter polymorphisms (1)
- FcgammaRII promoter polymorphisms (2)
- FcgammaRII promoter polymorphisms (3)
- Promoter polymorphism group distribution
- The ancestral haplotype
- Genetic associations with SLE
- How FcgammaRIIb polymorphism relates to SLE?
- Does infection drive predisposition to autoimmunity
- Why do SLE-associated polymorphisms persist
- Prevalence of SLE and FcgammaRIIb
- Distribution of the FcgammaRIIB T232 mutation
- Reduced FcgRIIB function protects against malaria
- Does FcgRIIb deficiency protect against malaria?
- Reduced parasitaemia in FcgammaRIIb-/- mice
- Less severe malaria in FcgammaRII deficient mice
- Increased phagocytosis in FcgRIIb-/- macroph. (1)
- Increased phagocytosis in FcgRIIb-/- macroph. (2)
- Upregulation of CD86 in FcgRIIb-/- macrophages
- Increased TNF-alpha in FcgammaRIIb-/- mice
- Increased anti-malarial Abs in FcgRIIb-/- mice
- Reduced FcgammaRIIB function protects people?
- Phagocytosis of P.falciparum trophozoites
- FcgRIIB T/T protects infants from severe malaria
- FcgRIIB T/T protects from bacterial infection
- FcgammaRIIb deficiency in mice
- Fc receptors: linking innate and acquired immunity
- Genetic loci associated with SLE
- SLE pathogenesis
- FcgammaR in patients with SLE
- FcgammaRIIIb: an unusual Fcgamma receptor
- FcgRIIIb CN correlates with surface expression
- FcgammaRIIIb deleted/copied region (1)
- FcgammaRIIIb deleted/copied region (2)
- FcgR-independent function and FcgRIIIb CN
- Neutrophils adhere to IgG coated slides
- Neutrophil adhesion correlates with FcgRIIIb CN (1)
- Neutrophil adhesion correlates with FcgRIIIb CN (2)
- Immune complex uptake and FcgRIIIb CN (1)
- Soluble FcgRIIIb correlates with copy number
- FcgammaRIIIb is important in neutrophil
- FcgRIIIb CN correlates with surface expression
- Neutrophil adhesion correlates with FcgRIIIb CN (3)
- Immune complex uptake and FcgRIIIb CN (2)
- Association of FcgammaRIIIb CN with disease
- Summary
- Acknowledgements
Topics Covered
- High and low affinity Fc receptors
- FcgRIIb: the inhibitory FcR
- An immune "brake"
- Effects on infection
- Strep. Pneumoniae
- Over-expression and autoimmunity
- Polymorphic variation in FcgRIIb
- Does infection drive genetic predisposition to autoimmunity?
- An activatory receptor
- Copy number variation and function
Links
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Talk Citation
Smith, K.G.C. (2009, June 30). Fc receptors: linking innate and acquired immunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved June 1, 2025, from https://doi.org/10.69645/LSDF5758.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Ken G C Smith has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
